Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate.
Distribution of Neuroendocrine Cells in the Transition Zone of the Prostate.
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DOI：
10.1155/2017/8541697
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发表时间：
2017
影响因子：
1.4
通讯作者：
Masumori N
中科院分区：
文献类型：
--
作者：
Kyoda Y;Ichihara K;Hashimoto K;Kobayashi K;Fukuta F;Masumori N
目标。探讨神经内分泌（NE）细胞在过渡区（TZ）的分布对良性前列腺增生（BPH）发展的影响。方法。我们回顾了本院接受根治性前列腺切除术的80例患者的标本，并评估了TZ内NE细胞的密度。组织学上分为3组：TZ内未见腺瘤性结节组（A组）、TZ内小结节周围上皮及间质正常组（B组）、TZ内大结节占位组（C组）。B组分别计数TZ内腺瘤内（腺瘤结节）和瘤外（正常组织）NE细胞。结果。A组22例，B组23例，C组35例。B组患者TZ内NE细胞的中位密度为2.80/mm2，显著高于A组的1.43/mm2和C组的0.61/mm2 （p < 0.001）。B组腺瘤外NE细胞的中位密度明显高于腺瘤内。结论。TZ小腺瘤周围有许多NE细胞。NE细胞可能以旁分泌方式影响BPH的初始生长。试验注册。我们的机构审查委员会批准的这项研究回顾性注册（#272-14）。
Objectives. To evaluate the distribution of neuroendocrine (NE) cells which may influence the development of benign prostatic hyperplasia (BPH) in the transition zone (TZ). Methods. We reviewed specimens from 80 patients who underwent radical prostatectomy in our institution and evaluated the density of NE cells in the TZ. They were histologically classified into 3 groups: those with no adenomatous nodule in the TZ (group A), those with small nodules with normal epithelium and stroma around them in the TZ (group B), and those with large nodules occupying the TZ (group C). In the patients of group B, intra-adenoma (adenomatous nodules) and extra-adenoma (normal tissue) NE cells in the TZ were separately counted. Results. There were 22, 23, and 35 patients in groups A, B, and C, respectively. The median density of NE cells in the TZ of group B patients, 2.80/mm2, was significantly higher than that of NE cells in group A, 1.43/mm2, and group C, 0.61/mm2 (p < 0.001). In group B, the median density of extra-adenoma NE cells was significantly higher than that of intra-adenoma. Conclusions. Many NE cells exist around small adenoma in the TZ. NE cells may influence the initial growth of BPH in a paracrine fashion. Trial Registration. This study approved by our institutional review board was retrospectively registered (#272-14).