Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population
复制标题
全基因组关联确定了中国汉族人群冠状动脉疾病的易感位点
DOI：
10.1038/ng.783
复制
发表时间：
2011-04-01
期刊：
影响因子：
30.8
通讯作者：
Wang, Qing K.
中科院分区：
文献类型：
--
作者：
Wang, Fan;Xu, Cheng-Qi;Wang, Qing K.
冠心病（Coronary artery disease，CAD）是我国每年死亡的主要疾病之一。以前在欧洲血统人群中的全基因组关联研究（GWAS）确定了CAD的几个遗传位点，但在中国人群中尚未报道此类研究。在这里，我们报告了一个三阶段的GWAS在中国汉族人群。我们在染色体6p24.1上的一个假定基因C6 orf 105中发现了rs6903956与CAD之间的新关联（P= 5.00 × 10−3，第2阶段验证;P= 3.00 × 10−3，P= 1.19 × 10− 8和P = 4.00 × 10− 3在三个独立的第3阶段复制群体中; P= 4.87 × 10−12，合并人群中的优势比= 1.51）。rs6903956的次要风险等位基因A与C6 orf 105 mRNA表达降低相关。我们报告了中国汉族人群中第一个冠心病的GWAS，并在C6 orf 105中发现了一个与冠心病易感性相关的SNP rs6903956。
Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted asC6orf105on chromosome 6p24.1 and CAD (P= 5.00 × 10−3, stage 2 validation;P= 3.00 × 10−3,P= 1.19 × 10−8andP= 4.00 × 10−3in three independent stage 3 replication populations;P= 4.87 × 10−12, odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreasedC6orf105mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, inC6orf105associated with susceptibility to CAD in this population.