Applying process analytical technology to biotech unit operations
Applying process analytical technology to biotech unit operations
复制标题
将过程分析技术应用于生物技术单元运营
DOI：
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复制
发表时间：
2006
期刊：
影响因子：
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通讯作者：
David Chilin
中科院分区：
文献类型：
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作者：
A. Rathore;Ashutosh Sharma;David Chilin
Case studies were run to test Process Analytical Technology applications for protein refolding, diafiltration, and cation exchange chromatography. It is shown that it is feasible to design control schemes that rely on measurement of product quality attributes and thereby enable real-time decisions. Implementation of these schemes should result in consistent product quality and high operational efficiency. However, these advantages are balanced by requirements of a higher level of process understanding for designing these schemes, and increased operational complexity during implementation. Increased consistency in product quality is likely to increase variability in step recovery, a parameter that is commonly considered an indicator of process consistency.
