The synthesis of amino-acid functionalized β-carbolines as topoisomerase II inhibitors
The synthesis of amino-acid functionalized β-carbolines as topoisomerase II inhibitors
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DOI：
10.1016/s0960-894x(01)00136-6
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发表时间：
2001-05-21
影响因子：
2.7
通讯作者：
Macdonald, TL
中科院分区：
文献类型：
--
作者：
Deveau, AM;Labroli, MA;Macdonald, TL
本文报道了与氮胞毒素和tryprostatins结构相关的氨基酸功能化β -碳碱衍生物的合成及其生物活性。这些化合物在H520和PC3细胞系中检测了它们的生长抑制特性，并检测了它们抑制拓扑异构酶ii介导的DNA松弛的能力。2001爱思唯尔科学有限公司版权所有。
The synthesis and biological activity of amino acid functionalized beta -carboline derivatives, which are structurally related to azatoxin and the tryprostatins, are reported. These compounds were assayed for their growth inhibition properties in H520 and PC3 cell lines and were examined for their abilities to inhibit topoisomerase II-mediated DNA relaxation. (C) 2001 Elsevier Science Ltd. All rights reserved.