The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis.
The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis.
复制标题
淀粉样蛋白及其前体在调节脑止血中的影响。
DOI：
10.1016/j.bbadis.2015.10.020
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
VanNostrand,WilliamE
中科院分区：
文献类型：
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作者：
VanNostrand,WilliamE
缺血性和出血性中风是导致血管性认知障碍和痴呆（VCID）的脑损伤的重要原因。这些有害事件主要是由于脑止血的破坏，脑血管和周围脑组织中血栓形成和纤维蛋白溶解途径之间的良好控制和微妙平衡。缺血和出血通常都与脑血管淀粉样β-蛋白（AAPs）沉积有关。在这一点上，黄芪直接和间接调节脑血栓形成和纤维蛋白溶解。此外，AßPP前体蛋白（AßPP）的主要同种型作为血栓形成前蛋白酶的有效抑制剂发挥作用。本文就近年来脑血管紧张素Ⅱ和A β PP对脑止血作用的研究进展作一综述。这篇文章是特刊的一部分，题为：血管对认知障碍和痴呆的贡献，由M。作者：Paul Murphy，Roderick A. Corriveau和Donna M.威尔科克
Ischemic and hemorrhagic strokes are a significant cause of brain injury leading to vascular cognitive impairment and dementia (VCID). These deleterious events largely result from disruption of cerebral hemostasis, a well-controlled and delicate balance between thrombotic and fibrinolytic pathways in cerebral blood vessels and surrounding brain tissue. Ischemia and hemorrhage are both commonly associated with cerebrovascular deposition of amyloid ß-protein (Aß). In this regard, Aß directly and indirectly modulates cerebral thrombosis and fibrinolysis. Further, major isoforms of the Aß precursor protein (AßPP) function as a potent inhibitor of pro-thrombotic proteinases. The purpose of this review article is to summarize recent research on how cerebral vascular Aß and AßPP influence cerebral hemostasis. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia, edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.