Non-HDL-cholesterol as valid surrogate to apolipoprotein B100 measurement in diabetes: Discriminant Ratio and unbiased equivalence.
Non-HDL-cholesterol as valid surrogate to apolipoprotein B100 measurement in diabetes: Discriminant Ratio and unbiased equivalence.
复制标题
DOI：
10.1186/1475-2840-10-20
复制
发表时间：
2011-02-28
影响因子：
9.3
通讯作者：
Rousseau MF
中科院分区：
文献类型：
--
作者：
Hermans MP;Sacks FM;Ahn SA;Rousseau MF
载脂蛋白B100（apoB）是比总胆固醇或LDL-C更好的CV风险上级指标。非HDL-C代表高脂血症和/或T2 DM患者中apoB的简单替代物。ApoB和non-HDL-C显示出高度相关性，尽管在CV风险评估中相互一致的程度仍存在争议。我们使用判别比（DR）方法比较非HDL-C与apoB的性能，根据血脂异常对糖尿病患者进行排名，并在考虑测量噪音和受试者内/受试者间变异的情况下建立这些变量之间的潜在关系，并推导出无偏等效方程。测定45例糖尿病患者空腹总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白B（apoB）和甘油三酯（TG）。基础受试者间标准差（SD）与受试者内标准差的DR由重复计算得出。调整配对之间的相关系数，以包括潜在相关性的估计。平均值[第1天（1 SD）]为143（36）mg/dl（非HDL-C）和98（24）mg/dl（apoB）。两个参数的DR相似（1.76和1.83）（p = 0.83）。检验间的皮尔逊积差相关系数非常高（0.94），经衰减调整后达到1（1.00）。apoB与非HDL-C相关的无偏等效方程的斜率为0.65，截距为6.3 mg/dl。根据致动脉粥样硬化胆固醇和脂蛋白负荷，非HDL-C与apoB对糖尿病患者进行分级的区分能力相似。由于变量之间的真实相关性达到统一，因此非HDL-C不仅可以提供代谢替代物，而且可以提供与apoB相当的候选生物统计学等效物，因为非HDL-C计算是容易获得的。
Apolipoprotein B100 (apoB) is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high correlation, although the degree of mutual concordance remains debated in CV risk evaluation. We used the Discriminant Ratio (DR) methodology to compare the performance of non-HDL-C with that of apoB to rank diabetic patients according to dyslipidemia and to establish the underlying relationship between these variables taking measurement noise and intra-/intersubject variation into account, and to derive an unbiased equivalence equation. Fasting total C, HDL-C, apoB and triglycerides were measured in 45 diabetic patients. The DR of the underlying between-subject standard deviation (SD) to the within-subject SD was calculated from duplicates. Correlation coefficients between pairs were adjusted to include an estimate of the underlying correlation. Mean values [day 1 (1SD)] were 143 (36) mg/dl (non-HDL-C) and 98 (24) mg/dl (apoB). The DR's of both parameters were similar (1.76 and 1.83) (p = 0.83). Pearson's product-moment correlation coefficient between tests was very high (0.94), reaching unity (1.00) after attenuation adjustment. The unbiased equation of equivalence relating apoB to non-HDL-C had a slope of 0.65 and an intercept of 6.3 mg/dl. The discrimination power of non-HDL-C is similar to that of apoB to rank diabetic patients according to atherogenic cholesterol and lipoprotein burden. Since true correlation between variables reached unity, non-HDL-C may provide not only a metabolic surrogate but also a candidate biometrical equivalent to apoB, as non-HDL-C calculation is readily available.