Parallel computing simulation of electrical excitation and conduction in the 3D human heart
Parallel computing simulation of electrical excitation and conduction in the 3D human heart
复制标题
3D 人体心脏电激励和传导的并行计算模拟
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Yi
中科院分区：
文献类型：
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作者：
Di Yu;D. Du;Hui Yang;Yi
正确跳动的心脏对于确保全身血液充分循环非常重要。正常的心律是由整个心脏的电信号精心传导产生的。心脏电活动是一系列复杂的生化机械反应的结果，涉及离子流通过各种生物离子通道的运输和生物分布。心律失常是由离子通道活性的直接改变引起的，导致 AP 波形的变化。在这项工作中，我们利用 GPGPU 和 OpenGL 的大规模并行计算开发了一个全心脏仿真模型。为了进行比较，仿真算法在多个不同版本下实现，包括一个传统CPU版本和两个基于Nvidia CUDA平台的GPU版本。 OpenGL被用于可视化/交互平台，因为它是开源的、轻量级的并且受到各种操作系统的普遍支持。实验结果表明，基于GPU的仿真优于传统的基于CPU的方法，显着提高了仿真速度。通过采用现代计算机架构，本研究能够在现实世界人类心脏的大型复杂 3D 几何结构中实时模拟和可视化电激励和传导。
A correctly beating heart is important to ensure adequate circulation of blood throughout the body. Normal heart rhythm is produced by the orchestrated conduction of electrical signals throughout the heart. Cardiac electrical activity is the resulted function of a series of complex biochemical-mechanical reactions, which involves transportation and bio-distribution of ionic flows through a variety of biological ion channels. Cardiac arrhythmias are caused by the direct alteration of ion channel activity that results in changes in the AP waveform. In this work, we developed a whole-heart simulation model with the use of massive parallel computing with GPGPU and OpenGL. The simulation algorithm was implemented under several different versions for the purpose of comparisons, including one conventional CPU version and two GPU versions based on Nvidia CUDA platform. OpenGL was utilized for the visualization / interaction platform because it is open source, light weight and universally supported by various operating systems. The experimental results show that the GPU-based simulation outperforms the conventional CPU-based approach and significantly improves the speed of simulation. By adopting modern computer architecture, this present investigation enables real-time simulation and visualization of electrical excitation and conduction in the large and complicated 3D geometry of a real-world human heart.