Fetal one-carbon nutrient concentrations may be affected by gestational diabetes
Fetal one-carbon nutrient concentrations may be affected by gestational diabetes
复制标题
DOI：
10.1016/j.nutres.2018.04.010
复制
发表时间：
2018-07-01
影响因子：
4.5
通讯作者：
Berger, Howard
中科院分区：
文献类型：
--
作者：
Barzilay, Eran;Moon, Ashley;Berger, Howard
妊娠期一碳营养素（叶酸、胆碱、维生素B6和B12）不足和过量均与妊娠期糖尿病（GDM）有关。然而，这种关联的确切性质尚未明确确定。我们假设GDM可能影响胎儿中的一碳营养素浓度，从而可能参与后代的表观遗传编程。在招募时（12-16周）采集母体血液。在分娩时（28-42周），采集母体和脐带血。比较两组血中一碳营养素及其代谢产物的浓度。共有368名妇女被纳入研究，其中19名（5.6%）后来被诊断为GDM。在招募或分娩时，GDM组和对照组之间的一碳营养素及其代谢产物的母体血液浓度无显著差异。然而，在脐带血中，血清叶酸（87.7 [IQR 70.4-103.9] vs 66.6 [IQR 45.5-80.3] nmol/L，P = 0.025）和血浆TMAO（2.82 [IQR 1.3-3.2] vs 1.35 [IQR 1.0-2.0] μ mol/L，P = 0.017）浓度较高，而GDM母亲所生婴儿的血浆甜菜碱浓度低于对照组（17.5 [IQR 16.3-19.4] vs 21.1 [IQR 18.0-24.1] μ mol/L，P = 0.019）。我们的数据表明，虽然母体血液中一碳营养素及其代谢产物的浓度可能不会影响GDM的风险，但GDM可能会改变血清叶酸，血浆甜菜碱和脐带血中TMAO的浓度。胎儿循环中一碳营养浓度的这些改变可能影响表观遗传编程，从而导致与GDM后代相关的成年期生理变化和疾病易感性。(C)2018爱思唯尔公司All rights reserved.
Both insufficiency and excess of one-carbon nutrients (folate, choline, vitamins B6 and B12) during pregnancy have been associated with gestational diabetes mellitus (GDM). However, the precise nature of this association has not been clearly established. We hypothesized that GDM may affect one-carbon nutrients concentrations in the fetus, thus possibly participating in epigenetic programing of the offspring. Maternal blood was collected at recruitment (12-16 weeks). At delivery (28-42 weeks), both maternal and cord blood were collected. Blood concentrations of one-carbon nutrients and their metabolites were compared between the two groups. A total of 368 women were included in the study, of whom 19 (5.6%) were later diagnosed with GDM. No significant differences were found in maternal blood concentrations of one-carbon nutrients and their metabolites between the GDM and control groups at recruitment or at delivery. In cord blood, however, serum folate (87.7 [IQR 70.4-103.9] vs 66.6 [IQR 45.5-80.3] nmol/L, P = .025) and plasma TMAO (2.82 [IQR 1.3-3.2] vs 1.35 [IQR 1.0-2.0] mu mol/L, P = .017) concentrations were higher, while plasma betaine concentrations were lower (17.5 [IQR 16.3-19.4] vs 21.1 [IQR 18.0-24.1] mu mol/L, P = .019) in infants born to mothers with GDM compared with control. Our data suggest that while maternal blood concentrations of one-carbon nutrients and their metabolites may not affect the risk of GDM, GDM may alter concentrations of serum folate, plasma betaine and TMAO in cord blood. These alterations in one-carbon nutrient concentrations in fetal circulation may impact epigenetic programing, thereby contributing to physiologic changes and disease susceptibility in adulthood associated with GDM offspring. (C) 2018 Elsevier Inc. All rights reserved.