Investigation of the Lipid-Modifying and Antiinflammatory Effects of Cornus mas L. Supplementation on Dyslipidemic Children and Adolescents
Investigation of the Lipid-Modifying and Antiinflammatory Effects of Cornus mas L. Supplementation on Dyslipidemic Children and Adolescents
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DOI：
10.1007/s00246-013-0693-5
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发表时间：
2013-10-01
影响因子：
1.6
通讯作者：
Sahebkar, Amirhossein
中科院分区：
文献类型：
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作者：
Asgary, Sedigheh;Kelishadi, Roya;Sahebkar, Amirhossein
山茱萸果实富含花色苷，具有抗炎和抗氧化活性。本研究旨在调查补充中药是否能改善血脂紊乱儿童和青少年的血脂状况和血管炎症。在这项随机临床试验中，40名9~16岁的血脂异常儿童和青少年被分为两组，分别在午餐和晚餐后服用中药50g(病例组，n=20)或继续正常饮食(对照组，n=20)。分别于实验前及实验3、6周后测定血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、载脂蛋白A-I(apo A-I)、载脂蛋白B(Apo B)、细胞间黏附分子-1(ICAM-1)、血管细胞黏附分子-1(VCAM-1)、C反应蛋白(CRP)及人体测量指标。试验6周后，CM组TC、TG、LDL-C、apo B、ICAM-1和VCAM-1水平显著低于基线水平，而高密度脂蛋白-C和apo A-I水平显著高于基线水平。试验6周后，对照组的所有这些参数，除了ICAM-1外，都没有显著改变。然而，组间比较显示，只有载脂蛋白A-I有显著差异(p=0.016)，而细胞间黏附分子-1有极显著差异(p=0.076)。体重指数、腰臀比或C反应蛋白在研究组之间没有显著差异。目前的研究结果显示，在血脂异常的儿童和青少年的日常饮食中添加CM后，血脂状况和血管炎症有改善的趋势，但这需要通过更大规模的试验来证实。
Cornus mas L. (CM) fruits are rich in anthocyanins and possess both antiinflammatory and antioxidant activities. The current study was conducted to investigate whether supplementation with CM could ameliorate lipid profile and vascular inflammation in dyslipidemic children and adolescents. In this randomized clinical trial, 40 dyslipidemic children and adolescents ages 9 to 16 years were assigned to receive 50 g of CM twice a day after lunch and dinner (n = 20, case group) or to continue their normal diet (n = 20, control group). The serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), apo A-I, apo B, intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), C-reactive protein (CRP), and anthropometric indices were determined at baseline and then after weeks 3 and 6 of the trial. After week 6 of the trial, the TC, TG, LDL-C, apo B, ICAM-1, and VCAM-1 levels in the CM group were significantly lower and the HDL-C and apo A-I levels higher than at baseline. After week 6 of the trial, none of these parameters in the control group, except for ICAM-1, was significantly altered from baseline. However, between-group comparison showed a significant difference only for apo A-I (p = 0.016) and a borderline significant difference for ICAM-1 (p = 0.076). No significant difference in body mass index, waist-to-hip ratio, or C-reactive protein was observed between the studied groups. The present findings revealed a trend toward amelioration of lipid profile and vascular inflammation following addition of CM to the daily diet of dyslipidemic children and adolescents but this needs to be verified by larger scale trials.