COLLAGEN-METABOLISM IN HUMAN AQUEOUS-HUMOR FROM PRIMARY OPEN-ANGLE GLAUCOMA - DECREASED DEGRADATION AND INCREASED BIOSYNTHESIS PLAY A ROLE IN ITS PATHOGENESIS
COLLAGEN-METABOLISM IN HUMAN AQUEOUS-HUMOR FROM PRIMARY OPEN-ANGLE GLAUCOMA - DECREASED DEGRADATION AND INCREASED BIOSYNTHESIS PLAY A ROLE IN ITS PATHOGENESIS
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DOI：
10.1001/archopht.1995.01100100107039
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发表时间：
1995-10-01
影响因子：
--
通讯作者：
SELMAN, M
中科院分区：
文献类型：
--
作者：
GONZALEZAVILA, G;GINEBRA, M;SELMAN, M
Objective: To explore the influence of aqueous humor from patients with glaucoma on collagen turnover.Methods: The aqueous humor of patients with primary open-angle glaucoma (POAG), chronic angle-closure glaucoma, congenital glaucoma, neovascular glaucoma, and senile cataract (control group) was analyzed for its capacity to induce fibroblast proliferation, collagen synthesis, collagenolytic activity, and production of tissue inhibitor of metalloproteinase-1. All data were analyzed using the Mann-Whitney U test.Results: Aqueous humor derived from patients with POAG induced a significant decrease of functional collagenase activity (mean +/- SE, 9.12+/-1.33 mu g of degraded collagen per milligram of incubated protein vs 20.94+/-4.14 mu g from the control group, P
