INTRACRANIAL SELF-STIMULATION IN RELATION TO THE ASCENDING NORADRENERGIC FIBER SYSTEMS OF THE PONTINE TEGMENTUM AND CAUDAL MIDBRAIN - MOVEABLE ELECTRODE MAPPING STUDY
INTRACRANIAL SELF-STIMULATION IN RELATION TO THE ASCENDING NORADRENERGIC FIBER SYSTEMS OF THE PONTINE TEGMENTUM AND CAUDAL MIDBRAIN - MOVEABLE ELECTRODE MAPPING STUDY
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DOI：
10.1016/0006-8993(79)90461-x
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发表时间：
1979-01-01
期刊：
影响因子：
2.9
通讯作者：
WISE, RA
中科院分区：
文献类型：
--
作者：
CORBETT, D;WISE, RA
慢性植入可移动电极被用来映射大鼠脑桥被盖和尾侧中脑颅内自我刺激的关系，上行去甲肾上腺素能系统所揭示的荧光组织化学。在没有测试的区域中，自我刺激的质量或存在与去甲肾上腺素能纤维密度或细胞聚集的程度之间存在一致的相关性。特别重要的是，尽管反复测试和广泛的行为塑造尝试，但未能从蓝斑获得自我刺激。这些支持自我刺激的区域包括中缝背核、上级小脑脚和三叉神经的中脑核和运动核。这些数据似乎排除了上行去甲肾上腺素能系统的激活作为这些领域的刺激的奖励效应的解释。一个味觉内脏纤维系统建议作为一种替代可能的基板。
Chronically implanted moveable electrodes were used to map the rat pontine tegmentum and caudal midbrain for intracranial self-stimulation in relation to the ascending noradrenergic systems as revealed by fluorescence histochemistry. In no area tested was there a consistent correlation between the quality or the presence of self-stimulation and the degree of noradrenergic fiber density or cellular aggregation. Of particular importance was the failure to obtain self-stimulation from the locus ceruleus, despite repeated testing and extensive attempts at behavioral shaping. Those areas supporting self-stimulation included the dorsal raphe nucleus, the superior cerebellar peduncle and the mesencephalic and motor nuclei of the trigeminal nerve. These data appear to rule out activation of the ascending noradrenergic systems as an explanation of the rewarding effects of stimulation in these areas. A gustatory-visceral fiber system is suggested as an alternative possible substrate.