How a broadly neutralizing antibody grapples with antigenic and conformational diversity in dengue virus.

How a broadly neutralizing antibody grapples with antigenic and conformational diversity in dengue virus.
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广泛中和抗体如何应对登革热病毒的抗原和构象多样性。

DOI:
10.1016/j.cell.2021.11.020
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发表时间:
2021
期刊:
影响因子:
64.5
通讯作者:
Lee,KellyK
Lee,KellyK
中科院分区:
生物学1区
文献类型:
--
作者:
Lee,KellyK

文献摘要

相似文献

在本期《细胞》杂志上,两项研究应用强大的结构方法来探索在四种登革热病毒血清型和寨卡病毒上发现的广泛中和抗体和保守表位之间的相互作用模式。这些发现为广泛中和抗体如何克服抗原和构象变异提供了新的见解。
In this issue ofCell,two studies apply powerful structural approaches to probe the modes of interaction between a broadly neutralizing antibody and a conserved epitope found on four dengue virus serotypes and Zika virus. These findings offer new insights into how a broadly neutralizing antibody surmounts antigenic and conformational variation.