Intakes of magnesium, potassium, and calcium and the risk of stroke among men
Intakes of magnesium, potassium, and calcium and the risk of stroke among men
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DOI：
10.1111/ijs.12516
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发表时间：
2015-10-01
影响因子：
6.7
通讯作者：
Rexrode, Kathryn M.
中科院分区：
文献类型：
--
作者：
Adebamowo, Sally N.;Spiegelman, Donna;Rexrode, Kathryn M.
背景：镁、钾和钙的摄入量与高血压的发病率呈负相关，高血压是中风的一个已知危险因素。然而，只有少数研究检查了这些阳离子的摄入量与中风风险的关系。目的本研究的目的是调查镁，钾和钙的高摄入量是否与男性中风风险降低有关。方法我们前瞻性地检查了饮食和补充剂中镁，钾和钙的摄入量之间的关系，在1986年健康专业人员随访研究中，42669名年龄在40至75岁之间，基线时未诊断出心血管疾病和癌症的男性发生中风的风险。我们使用多变量考克斯比例风险模型计算了每种阳离子摄入量的五分位数和所有三种阳离子的综合饮食评分的总风险比，缺血性和出血性中风，结果在24年的随访中，记录了1547例总中风事件。在多变量分析中，最高与最低五分位数男性总卒中的相对危险度和95%置信区间为0.87（95%置信区间，0.74-1.02; P，趋势= 0.04）（95%置信区间，0.76-1.05; P，趋势= 0.10）的膳食钾，和0.89（95%置信区间，0.75-1.04; P，趋势= 0.25）的膳食钙摄入量。最高与最低五分位数的男性总中风的相对风险为0.74（95%置信区间，0.59-0.93; P，趋势= 0.003）补充镁，0.66（95%置信区间，0.50-0.86; P，趋势= 0.002），补充钾摄入量为1.01（95%置信区间，0.84-1.20; P，趋势= 0.83）。总摄入量（饮食和补充），最高与最低五分位数男性总中风的相对风险为0.83（95%置信区间，0.70-0.99; P，趋势= 0.04），镁，0.88（95%置信区间，0.75-4; P，趋势= 6）和3（95%置信区间，79-09; P，趋势= 84）。男性在最高的五分之一的综合饮食评分的所有三种阳离子有一个多变量的相对风险为0.79（95%置信区间，0.67-0.92; P，趋势= 0.008）总中风，与那些在最低。结论饮食中富含镁，钾，钙可能有助于降低男性中风的风险。由于显着的共线性，每个阳离子的独立贡献是难以界定的。
Background Intakes of magnesium, potassium, and calcium have been inversely associated with the incidence of hypertension, a known risk factor for stroke. However, only a few studies have examined intakes of these cations in relation to risk of stroke.Aim The aim of this study was to investigate whether high intake of magnesium, potassium, and calcium is associated with reduced stroke risk among men.Methods We prospectively examined the associations between intakes of magnesium, potassium, and calcium from diet and supplements, and the risk of incident stroke among 42 669 men in the Health Professionals Follow-up Study, aged 40 to 75 years and free of diagnosed cardiovascular disease and cancer at baseline in 1986. We calculated the hazard ratio of total, ischemic, and haemorrhagic strokes by quintiles of each cation intake, and of a combined dietary score of all three cations, using multivariate Cox proportional hazard models.Results During 24 years of follow-up, 1547 total stroke events were documented. In multivariate analyses, the relative risks and 95% confidence intervals of total stroke for men in the highest vs. lowest quintile were 0.87 (95% confidence interval, 0.74-1.02; P, trend = 0.04) for dietary magnesium, 0.89 (95% confidence interval, 0.76-1.05; P, trend = 0.10) for dietary potassium, and 0.89 (95% confidence interval, 0.75-1.04; P, trend = 0.25) for dietary calcium intake. The relative risk of total stroke for men in the highest vs. lowest quintile was 0.74 (95% confidence interval, 0.59-0.93; P, trend = 0.003) for supplemental magnesium, 0.66 (95% confidence interval, 0.50-0.86; P, trend = 0.002) for supplemental potassium, and 1.01 (95% confidence interval, 0.84-1.20; P, trend = 0.83) for supplemental calcium intake. For total intake (dietary and supplemental), the relative risk of total stroke for men in the highest vs. lowest quintile was 0.83 (95% confidence interval, 0.70-0.99; P, trend = 0.04) for magnesium, 0.88 (95% confidence interval, 0.75-4; P, trend = 6) for potassium, and 3 (95% confidence interval, 79-09; P, trend = 84) for calcium. Men in the highest quintile for a combined dietary score of all three cations had a multivariate relative risk of 0.79 (95% confidence interval, 0.67-0.92; P, trend = 0.008) for total stroke, compared with those in the lowest.Conclusions A diet rich in magnesium, potassium, and calcium may contribute to reduced risk of stroke among men. Because of significant collinearity, the independent contribution of each cation is difficult to define.