Self versus informant reports on the specific levels of functioning scale: Relationships to depression and cognition in schizophrenia and schizoaffective disorder.
Self versus informant reports on the specific levels of functioning scale: Relationships to depression and cognition in schizophrenia and schizoaffective disorder.
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DOI：
10.1016/j.scog.2017.04.001
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发表时间：
2017-09-01
期刊：
影响因子：
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通讯作者：
Barch, Deanna M
中科院分区：
文献类型：
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作者：
Ermel, Julia;Carter, Cameron S;Barch, Deanna M
目前这项研究的目标是检查精神分裂症和分裂情感障碍患者的自知力与认知功能和抑郁之间的关系，并确定诊断类别之间是否存在类似的关系。我们考察了自我和告密者在功能量表的具体水平上对功能的报告之间的差异，以此来衡量对人际关系、社会接受、工作和活动的洞察力。我们检查了两个精神分裂症和/或分裂情感障碍患者的样本(NS分别为188和67)。在样本1中，使用点探测器预期任务来测量认知。在样本2中，通过对Matrics Consensus认知电池的几个子测试进行平均，以及额外的工作记忆测量来衡量认知能力。在这两个样本中，抑郁都是使用简明精神病学评定量表进行测量的。在这两个样本中，我们发现较差的认知与高估工作功能，以及较高的抑郁水平与低估人际功能之间存在显著关系。这些关系是特定于人际和工作功能的，与其他功能领域相比，与人际和工作功能的相关性明显更强。在诊断类别中也发现了类似的结果。这些结果对治疗计划具有重要的意义，因为它们表明在评估患者的自我功能报告时需要考虑抑郁和认知功能，并突出了信息者报告在评估功能和治疗计划中的效用。此外，他们增加了关于精神分裂症和分裂情感障碍在各种病理机制上的相似性的文献。
The goal of the current study was to examine the relationships between insight and both cognitive function and depression in schizophrenia and schizoaffective disorder, and to determine if there were similar relationships across diagnostic categories. We examined discrepancies between self and informant reports of function on the Specific levels of function scale as a metric of insight for interpersonal, social acceptance, work and activities. We examined two samples of individuals with schizophrenia and/or schizoaffective disorder (Ns of 188 and 67 respectively). In Sample 1, cognition was measured using the Dot Probe Expectancy Task. In Sample 2, cognition was measured by averaging several subtests from the MATRICS consensus cognitive battery, as well as additional measures of working memory. In both samples, depression was measured using the Brief Psychiatric Rating Scale. In both samples, we found significant relationships between worse cognition and overestimations of work function, as well as between higher depression levels and underestimation of interpersonal function. These relationships were specific to interpersonal and work function, with significantly stronger correlations with interpersonal and work function compared to the other areas of function. Similar results were found across diagnostic categories. These results have important implications for treatment planning, as they suggest the need to take into account depression and cognitive function when evaluating the patient's self-report of function, and highlight the utility of informant reports in evaluating function and treatment planning. Further, they add to the literature on the similarity across schizophrenia and schizoaffective disorder in a variety of pathological mechanisms.