Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
复制标题
硫限制通过下调核糖体，通过 Ecl1 家族基因延长裂殖酵母的时间寿命
DOI：
10.1111/mmi.13686
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发表时间：
2017
影响因子：
3.6
通讯作者：
and Hirofumi Aiba
中科院分区：
文献类型：
--
作者：
Hokuto Ohtsuka*;Masahiro Takinami*;Takafumi Shimasaki;Takahide Hibi;Hiroshi Murakami;and Hirofumi Aiba
众所周知，营养限制，如卡路里限制，可以延长各种生物的寿命。在这里，我们发现硫的限制延长了裂殖酵母的时间寿命(CLS)。这种限制减少了细胞大小、RNA含量和核糖体蛋白，增加了产孢率。这些反应依赖于Ecl1家族基因，Ecl1家族基因的过度表达导致了CLS的延伸。我们还发现，ZIP1转录因子导致ecl1+基因的硫限制表达。我们证明，核糖体活性的降低会导致CLS的延长。基于这些观察，我们认为硫限制通过Ecl1家族基因以核糖体活性依赖的方式扩展CLS。
Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeastSchizosaccharomyces pombe. The restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also showed that the Zip1 transcription factor results in the sulfur restriction‐dependent expression of theecl1+gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS. Based on these observations, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity‐dependent manner.