An assessment of triclosan susceptibility in methicillin-resistant and methicillin-sensitive Staphylococcus aureus
An assessment of triclosan susceptibility in methicillin-resistant and methicillin-sensitive Staphylococcus aureus
复制标题
DOI：
10.1016/s0195-6701(99)90047-6
复制
发表时间：
1999-02-01
影响因子：
6.9
通讯作者：
Neal, TJ
中科院分区：
文献类型：
--
作者：
Bamber, AI;Neal, TJ
三氯生被广泛用于减少葡萄球菌的皮肤定植，并被纳入耐甲氧西林金黄色葡萄球菌（MRSA）根除方案。采用琼脂稀释法测定了186株耐甲氧西林金黄色葡萄球菌（MRSA）和甲氧西林敏感金黄色葡萄球菌（MSSA）对三氯生的最低抑菌浓度（MIC）。检测到14株分离株（7.5%）的MIC大于或等于1.0 ppm。MSSA和MRSA对三氯生的耐药率无显著差异。显示低水平莫匹罗星抗性的16株MRSA中没有一株的MIC大于或等于1.0 ppm。当用于根除葡萄球菌携带时，葡萄球菌对三氯生的MIC增加可能导致治疗失败。我们建议现在可以进行葡萄球菌对三氯生的常规药敏试验。
Triclosan is widely used to reduce skin colonization with staphylococci and is incorporated into methicillin-resistant Staphylococcus aureus (MRSA) eradication regimes. Using an agar dilution method, the minimum inhibitory concentration (MIC) to triclosan was determined for 186 isolates of MRSA and methicillin sensitive Staphylococcus aureus (MSSA). Fourteen isolates (7.5%) were detected with a MIC greater than or equal to 1.0 part per million (ppm). There was no significant difference between the incidence of triclosan resistance in strains of MSSA and MRSA. None of 16 strains of MRSA which exhibited low-level mupirocin resistance had MIC's greater than or equal to 1.0 ppm. Increased MIC's of staphylococci to triclosan may contribute to treatment failure when used to eradicate staphylococcal carriage. We suggest that routine susceptibility testing of staphylococci against triclosan might now be indicated.