Auditory brainstem response demonstrates that reduced peripheral auditory input is associated with self-report of tinnitus.
Auditory brainstem response demonstrates that reduced peripheral auditory input is associated with self-report of tinnitus.
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DOI：
10.31219/osf.io/cm2ve
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发表时间：
2019-03
期刊：
影响因子：
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通讯作者：
Naomi F. Bramhall;G. McMillan;F. Gallun;D. Konrad‐Martin
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文献类型：
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作者：
Naomi F. Bramhall;G. McMillan;F. Gallun;D. Konrad‐Martin
耳鸣是耳蜗突触病的预测知觉后果之一，耳蜗突触病是一种年龄、噪音或药物引起的听觉损伤，已在动物模型中证明会导致中枢听觉增益的稳态变化。尽管在人类颞骨中观察到突触病，但对活人这种情况的评估仅限于间接非侵入性测量，例如听觉脑干反应（ABR）。在动物模型中，突触病与阈上刺激水平下 ABR 波 I 振幅的降低有关。几项人类研究探索了 I 波振幅与耳鸣之间的关系，但结果相互矛盾。本研究调查了由于突触/神经元损失而导致的外周听觉输入减少与耳鸣相关的假设。来自 193 名个体的 I 波振幅数据[43 名有耳鸣 (22%)，150 名无耳鸣 (78%)] 参与了 4 项不同研究中的 3 项，这些数据被纳入逻辑回归分析中，以估计各种刺激水平和频率下 I 波振幅与耳鸣之间的关系。包括性别和畸变产物耳声发射 (DPOAE) 的统计调整。结果表明，较小的 I 波幅度和/或较低的 DPOAE 水平与耳鸣的可能性增加有关。
Tinnitus is one of the predicted perceptual consequences of cochlear synaptopathy, a type of age-, noise-, or drug-induced auditory damage that has been demonstrated in animal models to cause homeostatic changes in central auditory gain. Although synaptopathy has been observed in human temporal bones, assessment of this condition in living humans is limited to indirect non-invasive measures such as the auditory brainstem response (ABR). In animal models, synaptopathy is associated with a reduction in ABR wave I amplitude at suprathreshold stimulus levels. Several human studies have explored the relationship between wave I amplitude and tinnitus, with conflicting results. This study investigates the hypothesis that reduced peripheral auditory input due to synaptic/neuronal loss is associated with tinnitus. Wave I amplitude data from 193 individuals [43 with tinnitus (22%), 150 without tinnitus (78%)], who participated in up to 3 out of 4 different studies, were included in a logistic regression analysis to estimate the relationship between wave I amplitude and tinnitus at a variety of stimulus levels and frequencies. Statistical adjustment for sex and distortion product otoacoustic emissions (DPOAEs) was included. The results suggest that smaller wave I amplitudes and/or lower DPOAE levels are associated with an increased probability of tinnitus.