A new splice variant of glial fibrillary acidic protein, GFAPε, interacts with the presenilin proteins
A new splice variant of glial fibrillary acidic protein, GFAPε, interacts with the presenilin proteins
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DOI：
10.1074/jbc.m112121200
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发表时间：
2002-08-16
影响因子：
4.8
通讯作者：
Jorgensen, AL
中科院分区：
文献类型：
--
作者：
Nielsen, AL;Holm, IE;Jorgensen, AL
我们描述了一种新的人类亚型，GFAP β，中间丝蛋白GFAP（胶质细胞酸性蛋白）。GFAP β mRNA是选择性剪接和新的多聚腺苷酸化信号的结果，因此GFAP β具有新的C端蛋白序列。这为GFAP β提供了在酵母中和体外特异性结合早老素蛋白的能力。我们的观察结果表明，早老素和GFAP β被纳入的细胞骨架之间的直接联系。GFAP和早老素突变分别与亚历山大病和阿尔茨海默病相关。因此，在研究神经退行性疾病时应考虑GFAP β。
We describe a new human isoform, GFAPepsilon, of the intermediary filament protein GFAP (glial fibrillary acidic protein). GFAPepsilon mRNA is the result of alternative splicing and a new polyadenylation signal, and thus GFAPepsilon has a new C-terminal protein sequence. This provides GFAPepsilon with the capacity for specific binding of presenilin proteins in yeast and in vitro. Our observations suggest a direct link between the presenilins and the cytoskeleton where GFAPepsilon is incorporated. Mutations in GFAP and presenilins are associated with Alexander disease and Alzheimer's disease, respectively. Accordingly, GFAPepsilon should be taken into consideration when studying neurodegenerative diseases.