Programmable NIR-II photothermal-enhanced starvation-primed chemodynamic therapy using glucose oxidase-functionalized ancient pigment nanosheets
Programmable NIR-II photothermal-enhanced starvation-primed chemodynamic therapy using glucose oxidase-functionalized ancient pigment nanosheets
复制标题
使用葡萄糖氧化酶功能化的古代色素纳米片进行可编程 NIR-II 光热增强饥饿引发的化学动力学疗法
DOI：
10.1002/smll.202001518
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发表时间：
2020
期刊：
影响因子：
13.3
通讯作者：
Peng Huang
中科院分区：
文献类型：
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作者：
Chen Yang;Muhammad Rizwan Younis;Jing Zhang;Junle Qu;Jing Lin;Peng Huang
近年来，化学动力学疗法（CDT）引起了人们的广泛关注，但其不良的反应动力学限制了其在临床上的实际应用。在此，开发了用于可编程近红外II（NIR-II）光热增强饥饿引发的CDT的葡萄糖氧化酶（GOx）官能化的古老颜料纳米片（SrCuSi 4 O 10，SC）。SC纳米片（SC NS）容易从水中的SC本体悬浮液剥离，随后用GOx官能化以形成纳米催化剂（表示为SC@G NS）。在激光照射下，SC NS的光热效应可以增强GOx对NIR-II光热增强饥饿疗法的催化活性，从而有效地消除肿瘤内的葡萄糖并产生丰富的过氧化氢（H2 O2）。重要的是，SC@G NS在第二生物窗中的高光热转换效率（46.3%）允许在NIR-II光声成像的指导下对深部肿瘤进行光热治疗。此外，由于葡萄糖酸的产生而导致的酸度放大将反过来加速SC NS的降解，促进锶（Sr）和铜（Cu）离子的释放。升高的H2 O2和释放的离子都将引发Cu 2 +/Sr 2 +-H2 O2反应，以增强CDT。因此，建立了一种可编程的NIR-II光热增强饥饿启动CDT，以对抗癌症，副作用最小。
Chemodynamic therapy (CDT) has attracted considerable attention recently, but the poor reaction kinetics restrict its practical utility in clinic. Herein, glucose oxidase (GOx) functionalized ancient pigment nanosheets (SrCuSi4O10, SC) for programmable near‐infrared II (NIR‐II) photothermal‐enhanced starvation primed CDT is developed. The SC nanosheets (SC NSs) are readily exfoliated from SC bulk suspension in water and subsequently functionalized with GOx to form the nanocatalyst (denoted as SC@G NSs). Upon laser irradiation, the photothermal effect of SC NSs can enhance the catalytic activity of GOx for NIR‐II photothermal‐enhanced starvation therapy, which effectively eliminates intratumoral glucose and produces abundant hydrogen peroxide (H2O2). Importantly, the high photothermal‐conversion efficiency (46.3%) of SC@G NSs in second biological window permits photothermal therapy of deep‐seated tumors under the guidance of NIR‐II photoacoustic imaging. Moreover, the acidity amplification due to gluconic acid generation will in turn accelerate the degradation of SC NSs, facilitating the release of strontium (Sr) and copper (Cu) ions. Both the elevated H2O2and the released ions will prime the Cu2+/Sr2+‐H2O2reaction for enhanced CDT. Thus, a programmable NIR‐II photothermal‐enhanced starvation primed CDT is established to combat cancer with minimal side effects.