Clinicopathological Significance of S100A10 Expression in Lung Adenocarcinomas.
Clinicopathological Significance of S100A10 Expression in Lung Adenocarcinomas.
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DOI：
10.7314/apjcp.2016.17.1.289
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
K. Katono;Yuichi Sato;Shi‐Xu Jiang;Makoto Kobayashi;Keita Saito;R. Nagashio;S. Ryuge;Y. Satoh
中科院分区：
文献类型：
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作者：
K. Katono;Yuichi Sato;Shi‐Xu Jiang;Makoto Kobayashi;Keita Saito;R. Nagashio;S. Ryuge;Y. Satoh
背景S100A10是S100蛋白家族的一员，据报道参与了癌细胞的侵袭和转移。本研究的目的是免疫组织化学检测S100A10在手术切除的肺腺癌中的表达，并评估其与患者临床病理参数和预后的关系。材料与方法对202例连续切除的肺腺癌组织中S100A10的表达进行免疫组化研究，并评价其与临床病理参数的相关性。采用Kaplan-Meier生存分析和Cox比例风险模型估计S100A10表达对生存的影响。结果202例肺腺癌中有65例（32.2%）表达S100A10，与较差的分化（P= 0.015）、较高的病理TNM分期（II期和III期）（P=0.004）、较频繁和严重的瘤内血管侵犯（P=0.001）、较差的预后（P=0.030）显著相关。然而，在控制了临床病理因素后，S100A10的表达并不是生存的独立预测因子。结论本研究显示S100A10在肺腺癌的一个亚群中表达，且与一些临床病理参数有关，但S100A10表达与肺腺癌患者预后的相关性有待进一步研究证实。
BACKGROUND S100A10, of the S100 protein family, is reported to be involved in cancer cell invasion and metastasis. The aims of the present study were to immunohistochemically examine S100A10 expression in surgically resected lung adenocarcinomas, and evaluate any relationships with clinicopathological parameters and prognosis of patients. MATERIALS AND METHODS S100A10 expression was immunohistochemically studied in 202 consecutive resected lung adenocarcinomas, and its associations with clinicopathological parameters were evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of S100A10 expression on survival. RESULTS S100A10 expression was detected in 65 of the 202 (32.2%) lung adenocarcinomas, being significantly correlated with poorer differentiation (P =0.015), a higher pathological TNM stage (stages II and III) (P=0.004), more frequent and severe intratumoral vascular invasion (P=0.001), and a poorer prognosis (P=0.030). However, S100A10 expression was not an independent predictor of survival after controlling for clinicopathological factors. CONCLUSIONS The present study reveals that S100A10 is expressed in a subset of lung adenocarcinomas, and this is related to some clinicopathological parameters, although further studies are required to confirm the correlation between S100A10 expression and prognosis of lung adenocarcinoma patients.