A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells
A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells
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DOI：
10.1159/000236899
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Svendsen, Clive N.
中科院分区：
文献类型：
--
作者：
Bhattacharyya, Anita;McMillan, Erin;Svendsen, Clive N.
唐氏综合征（DS）是一种发育障碍性疾病，其智力障碍是由于皮质发育缺陷所致。来自胎儿DS皮质的人神经祖细胞（hNPC）最初产生正常数量的神经元，但随着培养时间的推移产生较少的神经元，类似于体内DS中发生的神经发生模式。在这个关键时刻，DS hNPC的微阵列分析揭示了指示中间神经元祖细胞发育缺陷的基因变化。此外，参与神经祖细胞生物学的许多基因的表达失调表明祖细胞群的变化和随后的中间神经元神经发生的减少。在DS的中间神经元发育的一个关键时期的描绘提供了一个基础，减少神经发生的基础DS的调查和定义的时间，当这些祖细胞可能适合治疗性治疗。版权所有（C）2009 S. Karger AG，巴塞尔
Down syndrome (DS) is a developmental disorder whose mental impairment is due to defective cortical development. Human neural progenitor cells (hNPCs) derived from fetal DS cortex initially produce normal numbers of neurons, but generate fewer neurons with time in culture, similar to the pattern of neurogenesis that occurs in DS in vivo. Microarray analysis of DS hNPCs at this critical time reveals gene changes indicative of defects in interneuron progenitor development. In addition, dysregulated expression of many genes involved in neural progenitor cell biology points to changes in the progenitor population and subsequent reduction in interneuron neurogenesis. Delineation of a critical period in interneuron development in DS provides a foundation for investigation of the basis of reduced neurogenesis in DS and defines a time when these progenitor cells may be amenable to therapeutic treatment. Copyright (C) 2009 S. Karger AG, Basel