Adipocyte fatty acid binding protein in a Caucasian population: a new marker of metabolic syndrome?
Adipocyte fatty acid binding protein in a Caucasian population: a new marker of metabolic syndrome?
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DOI：
10.1111/j.1365-2362.2006.01696.x
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发表时间：
2006-09-01
影响因子：
5.5
通讯作者：
Karpisek, M.
中科院分区：
文献类型：
--
作者：
Stejskal, D.;Karpisek, M.
背景脂肪细胞脂肪酸结合蛋白（A-FABP）在代谢综合征的发病机制中起重要作用。本研究的目的是评估血清A-FABP作为代谢综合征的标志物，并评估其预测准确性在高加索population.Materials和方法进行人体测量和血清分析的体重指数（BMI），腰围，A-FABP，胰岛素，甘油三酯，总胆固醇，高密度脂蛋白胆固醇（HDL-c），低密度脂蛋白胆固醇（LDL-c），尿酸，67名非肥胖健康受试者和71名代谢综合征受试者的血糖水平。结果代谢综合征患者血清A-FABP水平显著高于健康对照组（平均42.4vs.23.7 μ g L-1，P < 0.01）;血清A-FABP水平与空腹胰岛素水平相关（r = 0.34; P < 0.01），葡萄糖（r = 0.21; P = 0.01），甘油三酯（r = 0.4; P < 0.01），BMI（r = 0.57; P < 0.01）和腰围（r = 0.51; P < 0.01），而与HDL-c（r = -0.23; P < 0.01）和Quicki（r = -0.32; P < 0.01）呈负相关。在A-FABP水平为16.4 μ g L-1时，A-FABP与代谢综合征诊断的敏感性为40%，特异性为99%。结论在高加索人群中，A-FABP水平可能是代谢综合征的独立标志物。
Backround Adipocyte fatty acid binding protein (A-FABP) has been suggested as playing an important role in the pathogenesis of metabolic syndrome. The aim of this study was to evaluate serum A-FABP as a marker of metabolic syndrome and to assess its predictive accuracy in a Caucasian population.Materials and methods Anthropometric and serum analyses were performed for body mass index (BMI), waist circumference, A-FABP, insulin, triglycerides, total cholesterol, high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), uric acid, and glucose on 67 non-obese, healthy subjects and 71 subjects with metabolic syndrome. Quicki-quantitative insulin sensitivity check index, receiver operating characteristic curve (ROC-curve) and chi(2) analysis were completed.Results Compared with healthy controls, subjects with metabolic syndrome had a significantly higher A-FABP serum level (mean: 42.4 vs. 23.7 mu g L-1; P < 0.01). The A-FABP serum level correlated with fasting levels of insulin (r = 0.34; P < 0.01), glucose (r = 0.21; P = 0.01), triglycerides (r = 0.4; P < 0.01), BMI (r = 0.57; P < 0.01) and waist circumference (r = 0.51; P < 0.01), but negatively with HDL-c (r = -0.23; P < 0.01) and Quicki (r = -0.32; P < 0.01). The relationship was defined between serum A-FABP level and metabolic syndrome diagnosis with 40% sensitivity and 99% specificity at A-FABP level 16.4 mu g L-1.Conclusions Serum A-FABP level might be an independent marker of metabolic syndrome in a Caucasian population.