Intradermal leukotriene B4, but not prostaglandin E2, induces itch-associated responses in mice
Intradermal leukotriene B4, but not prostaglandin E2, induces itch-associated responses in mice
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DOI：
10.1016/s0014-2999(98)00440-3
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发表时间：
1998-07-17
影响因子：
5
通讯作者：
Kuraishi, Y
中科院分区：
文献类型：
--
作者：
Andoh, T;Kuraishi, Y
研究了皮内注射白三烯B-4和前列腺素E对小鼠瘙痒相关反应的影响。白三烯B-4(0.001~1nmol/位)可引起注射部位的划痕，剂量-反应曲线呈钟形，在0.03nmol/位处达到峰值。白三烯B-4(0.03nmol/位)的作用在3min内开始，在第2个10min达到高峰，30min后几乎消退，并被白三烯B-4受体拮抗剂ONO-4057，5-[2-(2-carboxyethyl)-3-(6-(p-methoxyphenyl)-5E-hexenyl)氧苯氧基]戊酸同时注射所抑制。前列腺素E-2(0.003-300nmol/位)对皮肤无明显抓挠作用。这一结果提出了白三烯B-4是皮肤内源性瘙痒介质的可能性。(C)1998 Elsevier Science B.V.保留所有权利。
The itch-associated responses induced by intradermal injection of leukotriene B-4 and prostaglandin E were studied in mice. Leukotriene B-4 (0.001-1 nmol/site) elicited scratching of the injected site; the dose-response curve was bell-shaped with a peak effect at 0.03 nmol/site. The effect of leukotriene B-4 (0.03 nmol/site) started within 3 min, peaked in the second l0-min period, had almost subsided by 30 min, and was inhibited by the simultaneous injection of the leukotriene B-4 receptor antagonist ONO-4057, 5-[2-(2-carboxyethyl)-3-(6-(p-methoxyphenyl)-5E-hexenyl) oxyphenyoxy] valeric acid. Prostaglandin E-2 (0.003-300 nmol/site) did not significantly elicit scratching. The results raise the possibility that leukotriene B-4 is an endogenous itch mediator in the skin. (C) 1998 Elsevier Science B.V. All rights reserved.