Evoked potential versus behavior to detect minor insult to the spinal cord in a rat model
Evoked potential versus behavior to detect minor insult to the spinal cord in a rat model
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DOI：
10.1016/j.jocn.2008.08.009
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发表时间：
2009-08-01
影响因子：
2
通讯作者：
All, Angelo H.
中科院分区：
文献类型：
--
作者：
Agrawal, Gracee;Thakor, Nitish V.;All, Angelo H.
脊髓损伤的研究需要可靠的结果测量，以关键地评估损伤的严重程度和此后的恢复。然而，这种测量有时会受到手术过程中脊髓轻微损伤的影响，包括椎板切除术。空场Basso、Beattie和Bresna han(BBB)行为运动评分是主观的，容易出现人为错误。我们研究了体感诱发电位(SEP)作为评估损伤后脊髓完整性的电生理指标。在我们的实验中，对照组大鼠在椎板切除过程中受到轻微的无意脊髓损伤，SEP幅度下降了16%到18%，大约在7天内恢复。然而，在同一时期，相同动物的血脑屏障评分没有变化。与BBB相比，这突出了SEP对轻微侮辱的敏感性。这些差异可能有助于准确评估脊髓损伤的严重程度和进展，以及随后的恢复。(C)2008爱思唯尔有限公司。保留所有权利。
Reliable outcome measurement is needed for spinal cord injury research to critically evaluate the severity of injury and recovery thereafter. However, such measurements can sometimes be affected by minor, injury to the spinal cord during Surgical Procedures, including laminectomy. The open-field Basso, Beattie and Bresnahan (BBB) behavior motor scores are subjective and prone to human error. We investigated somatosensory evoked potential (SEP) as an electrophysiological measure to assess the integrity of the spinal cord after injury. In our experiment, control rats with a minor unintentional spinal cord insult during laminectomy showed a decrease in SEP amplitude by 16% to 18%, which recovered in around 7 days. However, there was no change in the BBB scores for the same animals over the same period. This highlights the sensitivity of SEP to minor insult as compared to BBB. These differences may be beneficial in accurate evaluation of the severity and progression of spinal Cord injury, and subsequent recovery. (C) 2008 Elsevier Ltd. All rights reserved.