Association between sugar and starch intakes and type 2 diabetes risk in middle-aged adults in a prospective cohort study
Association between sugar and starch intakes and type 2 diabetes risk in middle-aged adults in a prospective cohort study
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DOI：
10.1038/s41430-021-01005-1
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发表时间：
2021-09-20
影响因子：
4.7
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Kanehara, Rieko;Goto, Atsushi;Tsugane, Shoichiro
目的：我们的目的是调查糖或淀粉的摄入量和2型糖尿病（T2 D）的风险之间的关联在中年日本adultes.SubjecTS/METHODS：参与者包括27,797名男性和36,880名女性，年龄在45-75岁，没有糖尿病和危重病的历史之前，在日本公共卫生中心的前瞻性研究的第二次调查。我们使用经过验证的147项食物频率问卷计算了糖（总糖，总果糖和糖亚型）和淀粉摄入量（%能量/d），以估计前一年的平均饮食摄入量。T2 D发作由经验证的自我报告定义。调整潜在的混杂因素的OR估计使用多元Logistic回归分类和三次样条models.Results：在5年的随访，690名男性和500名女性被确定为T2 D。在女性中，总糖或总果糖摄入量的四分位数与T2 D风险无显著相关性;然而，样条曲线显示，在极高的摄入水平下，风险增加（OR [95% CI]：30%能量/d时总糖为1.88 [1.07-3.31]，14%能量/d时总果糖为1.87 [1.10-3.16]）。在分类和样条模型中，淀粉摄入量与女性T2 D风险呈正相关（OR [95% CI]：1.55 [1.13-2.12]，50%能量/d）。在男性中，糖和淀粉的摄入量与T2 D risk.CONCLUSIONS：在这项大规模的基于人群的队列研究中，淀粉摄入量与日本女性T2 D风险增加相关。不能忽视女性摄入极高的总糖或总果糖会增加风险。
OBJECTIVES: We aimed to investigate the association between sugar or starch intake and the risk of type 2 diabetes (T2D) in middle-aged Japanese adults.SUBJECTS/METHODS: Participants comprised 27,797 men and 36,880 women aged 45-75 years with no history of diabetes and critical illness before the second survey in the Japan Public Health Center-based Prospective Study. We calculated sugar (total sugar, total fructose, and sugar subtypes) and starch intakes (% energy/d) using a validated 147-item food frequency questionnaire, to estimate the average dietary intake over the previous year. T2D onset was defined by validated self-reports. ORs adjusted for potential confounders were estimated using multiple logistic regression with categorical and cubic spline models.RESULTS: During the 5-year follow-up, 690 men and 500 women were identified with T2D. In women, the quartiles of total sugar or total fructose intakes were not significantly associated with T2D risk; however, the spline curves showed an increased risk at extremely high intake levels (ORs [95% CI]: 1.88 [1.07-3.31] at 30% energy/d for total sugar and 1.87 [1.10-3.16] at 14% energy/d for total fructose). Starch intake was positively associated with T2D risk among women in the categorical and spline models (ORs [95% CI]: 1.55 [1.13-2.12] at 50% energy/d). In men, sugar and starch intakes were not associated with T2D risk.CONCLUSIONS: In this large-scale population-based cohort study, starch intake was associated with an increased T2D risk in Japanese women. An increased risk with extremely high intake of total sugar or total fructose among women cannot be disregarded.