Measurement of an Elasticity Map in the Human Cornea.
Measurement of an Elasticity Map in the Human Cornea.
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DOI：
10.1167/iovs.15-18248
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发表时间：
2016-06-01
影响因子：
4.4
通讯作者：
Juhasz T
中科院分区：
文献类型：
--
作者：
Mikula ER;Jester JV;Juhasz T
角膜的生物力学性质在决定角膜的形状和视力方面具有重要作用。由于角膜是一种非均匀的组织，因此认为整个角膜的弹性特性是不同的。我们的目标是测量整个角膜的角膜弹性图。声辐射力弹性显微镜（ARFEM）用于创建人角膜的角膜弹性图。该ARFEM使用低频、高强度声力来移位飞秒激光产生的微泡，同时使用高频、低强度超声来监测微泡在角膜内的位置。根据气泡的位移和声辐射力的大小，计算出位移方向上角膜弹性的局部值。在6个位置进行测量，从中央到周边角膜的前部和后部深度。中心、中间和周边区域的平均前部弹性模量分别为4.2 ± 1.2、3.4 ± 0.7和1.9 ± 0.7 kPa，而相同径向位置的后部弹性模量分别为2.3 ± 0.7、1.6 ± 0.3和2.9 ± 1.2 kPa。我们发现，在整个角膜的轴向和径向上有一个独特的弹性分布。
The biomechanical properties of the cornea have an important role in determining the shape of the cornea and visual acuity. Since the cornea is a nonhomogeneous tissue, it is thought that the elastic properties vary throughout the cornea. We aim to measure a map of corneal elasticity across the cornea. An acoustic radiation force elasticity microscope (ARFEM) was used to create a map of corneal elasticity in the human cornea. This ARFEM uses a low frequency, high intensity acoustic force to displace a femtosecond laser-generated microbubble, while using a high frequency, low intensity ultrasound to monitor the position of the microbubble within the cornea. From the displacement of the bubble and the magnitude of the acoustic radiation force, the local value of corneal elasticity is calculated in the direction of the displacement. Measurements were conducted at 6 locations, ranging from the central to peripheral cornea at anterior and posterior depths. The mean anterior elastic moduli were 4.2 ± 1.2, 3.4 ± 0.7, and 1.9 ± 0.7 kPa in the central, mid, and peripheral regions, respectively, while the posterior elastic moduli were 2.3 ± 0.7, 1.6 ± 0.3, and 2.9 ± 1.2 kPa in the same radial locations. We found that there is a unique distribution of elasticity axially and radially throughout the cornea.