[Effects of Songling Xuemaikang Capsule on ambulatory blood pressure in treatment of essential hypertension: a single-blind randomized controlled trial].
[Effects of Songling Xuemaikang Capsule on ambulatory blood pressure in treatment of essential hypertension: a single-blind randomized controlled trial].
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DOI：
10.3736/jcim20090603
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发表时间：
2009-06-01
期刊：
影响因子：
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通讯作者：
Wang, Sheng-Lian
中科院分区：
文献类型：
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作者：
Fu, Li;Mao, Zhen-Xing;Wang, Sheng-Lian
目的：探讨Ca(2+)通道拮抗剂、血管紧张素受体拮抗剂等西药联合平肝潜阳中药松龄血脉康胶囊（SXC）对24小时动态血压监测（ABPM）血压指标的影响，并评价SXC降压效果及稳定性。方法：70例原发性高血压患者。 2级或3级随机分为常规组和SXC组。每组各35例。常规组患者给予左旋氨氯地平2.5 mg、替米沙坦40 mg，每日1次；SXC组患者在左旋氨氯地平、替米沙坦治疗基础上，口服SXC 1.5 g，每日3次。他们都接受了两周的治疗。治疗前后测量24小时ABPM、谷峰比、平滑指数。结果:两组24小时昼夜平均收缩压(SBP)及24小时昼夜SBP负荷较治疗前均降低(P < 0.05)。西药联合SXC治疗血压降低效果优于西药治疗（P < 0.05）。西药联合SXC对舒张压（DBP）的影响较西药显着（P < 0.05）。 SXC组心率较治疗前及常规组降低（P < 0.05）。 SXC组谷峰比高于常规组，而平滑度指数两组间无显着性差异。两组血压晨峰均较治疗前有所改善（P < 0.05），且两组血压晨峰比较差异有统计学意义（P < 0.05）。结论：西药联合SXC对降低心率、血压尤其是SBP和SBP负荷具有长效作用。 SXC加西药对早晨血压飙升也有抑制作用。
OBJECTIVE: To explore the effects of Western medicine including Ca(2+) channel antagonist and angiotensin-receptor antagonist combined with Songling Xuemaikang Capsule (SXC), a compound traditional Chinese herbal medicine for calming liver and suppressing liver yang, on blood pressure indexes derived from 24-hour ambulatory blood pressure monitoring (ABPM), and to evaluate the effects and stability of SXC in lowering blood pressure.METHODS: Seventy patients with essential hypertension of grade 2 or grade 3 were randomly assigned to routine group and SXC group. There were 35 cases in each group. The patients in the routine group were administered with 2.5 mg levoamlodipine and 40 mg telmisartan once daily, and 1.5 g SXC was administered orally to the patients in the SXC group three times daily besides levoamlodipine and telmisartan treatment. They were all treated for two weeks. Twenty-four-hour ABPM, trough to peak ratio and smoothness index were measured before and after the treatment.RESULTS: Twenty-four-hour, day and night average systolic blood pressure (SBP) and 24-hour, day and night SBP load in the two groups were lowered as compared with before treatment (P < 0.05). The effects of Western medicine combined with SXC on blood pressure depression were better than those of Western medicine (P < 0.05). Western medicine combined with SXC had a significant influence on diastolic blood pressure (DBP) as compared with Western medicine (P < 0.05). The heart rate in the SXC group was reduced as compared with before treatment and the routine group (P < 0.05). Trough to peak ratio in SXC group was higher than that in the routine group, while there was no significant difference in smoothness index between the two groups. Morning surge in blood pressure in the two groups was improved as compared with before treatment (P < 0.05), and there was a significant difference in morning surge in blood pressure between the two groups (P < 0.05).CONCLUSION: Western medicine combined with SXC has long-lasting effects in lowering heart rate and blood pressure, especially for SBP and SBP load. SXC plus Western medicine also has an inhibition effect on morning surge in blood pressure.