Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats.
Environmental enrichment attenuates cue-induced reinstatement of sucrose seeking in rats.
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DOI：
10.1097/fbp.0b013e32831c3b18
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发表时间：
2008-12
影响因子：
1.6
通讯作者：
Harkness JH
中科院分区：
文献类型：
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作者：
Grimm JW;Osincup D;Wells B;Manaois M;Fyall A;Buse C;Harkness JH
这项研究检查了环境富集对禁食蔗糖 1 个月的大鼠寻找蔗糖的影响，测量方法是通过对先前与 10% 蔗糖自我给药相关的音调 + 光提示的反应来测量。大鼠要么在整个研究过程中被富集（实验1），要么仅在蔗糖自我施用训练后（实验2）。浓缩包括将大鼠成对饲养或将四只大鼠（ENR4）分组在一个大环境中，两者都带有新物体。对照（CON）单独放置，没有新物体。在实验 1 中，与 CON 大鼠相比，ENR4 大鼠对蔗糖配对提示的反应较少，但这种差异不具有统计学意义。相比之下，实验 2 中 ENR4 大鼠相对于 CON 大鼠的反应下降是显着且显着的。这些发现以及其他实验室的发现支持了这样一种假设，即丰富可能为个体提供更强的区分奖励可用性的能力。这可能会降低复发行为的脆弱性。因此，这些结果与饮食失调和毒瘾（以复发为特征的疾病）相关。
This study examined the effect of environmental enrichment on sucrose seeking in rats made abstinent from sucrose for 1 month, as measured by response for a tone + light cue previously associated with 10% sucrose self-administration. Rats were either enriched throughout the study (experiment 1) or only after sucrose self-administration training (experiment 2). Enrichment consisted of either housing the rats in pairs or grouping four rats (ENR4) in a large environment, both with novel objects. Controls (CON) were singly housed without novel objects. In experiment 1, ENR4 rats responded less to the sucrose-paired cue versus CON rats, but this difference was not statistically significant. In contrast, the decrease in response of ENR4 rats versus CON rats in experiment 2 was dramatic and significant. These findings, along with findings from other laboratories, support a hypothesis that the enrichment may provide individuals with a greater ability to discriminate the availability of reward. This may impart a decreased vulnerability to relapse behavior. Therefore, these results are relevant to both eating disorder and drug addiction – disorders characterized by relapse.