Prostate Cancer and Aspirin Use: Synopsis of the Proposed Molecular Mechanisms.
Prostate Cancer and Aspirin Use: Synopsis of the Proposed Molecular Mechanisms.
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DOI：
10.3389/fphar.2017.00145
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发表时间：
2017
影响因子：
5.6
通讯作者：
Abou-Kheir W
中科院分区：
文献类型：
--
作者：
Bilani N;Bahmad H;Abou-Kheir W
背景：前列腺癌(Pca)是一种严重的健康负担，影响着全世界数百万男性的发病率和死亡率。大多数前列腺癌患者最初对雄激素剥夺治疗敏感，但后来对治疗产生抵抗，最终死于转移性去势抵抗型前列腺癌(CRPC)。尽管新开发的抗雄激素疗法有效地缓解了患者的症状，延长了患者的生命，但CRPC仍没有治愈的方法。最近，统计研究表明，长期使用阿司匹林可能与前列腺癌患者的较好结果显著相关。通过这篇综述，我们的目的是确定阿司匹林与前列腺癌病理生物学相关的不同分子机制，重点是在这一背景下所做的基础研究。方法：应用计算机检索PubMed和MEDLINE数据库1946/2016-09期间的文章。使用与PCA和阿司匹林相关的关键词和组合进行搜索。由两位独立的评价者研究文章摘要，然后对符合我们审查目标的相关文章进行数据提取。结果：非甾体抗炎药阿司匹林通过COX依赖和COX非依赖两种机制影响PCa细胞的增殖、凋亡、耐药和转移。它还降低了前列腺癌诊断标记前列腺特异性抗原(PSA)的水平，这表明临床医生至少需要意识到他们的患者是否长期使用阿司匹林。结论：阿司匹林激活的信号级联反应值得进一步研究，这可能会带来新的知识，可能应用于改善PCa的诊断、预后和治疗。
Background: Prostate cancer (PCa) is a critical health burden, impacting the morbidity and mortality of millions of men around the world. Most of the patients with PCa have their disease at first sensitive to androgen deprivation treatments, but later they develop resistance to therapy and eventually die of metastatic castration-resistant prostate cancer (CRPC). Although the newly developed anti-androgen therapies are effectively alleviating symptoms and prolonging lives of patients, there are still no curable treatments for CRPC. Recently, statistical studies have shown that the chronic use of aspirin might be significantly associated with better outcomes in PCa patients. Through this review, we aim to identify the different proposed molecular mechanisms relating aspirin to the pathobiology of PCa neoplasms, with a major focus on basic research done in this context. Methods: Articles were retrieved via online database searching of PubMed and MEDLINE between 1946 and September 2016. Keywords and combinations related to PCa and aspirin were used to perform the search. Abstracts of the articles were studied by two independent reviewers and then data extraction was performed on the relevant articles that met our review objectives. Results: Aspirin, a non-steroidal anti-inflammatory drug (NSAID), affects the proliferation, apoptosis, resistance and metastasis of PCa cell lines, through both COX-dependent and COX-independent mechanisms. It also lowers levels of the PCa diagnostic marker prostate specific antigen (PSA), suggesting that clinicians need to at least be aware if their patients are using Aspirin chronically. Conclusion: This review strongly warrants further consideration of the signaling cascades activated by aspirin, which may lead to new knowledge that might be applied to improve diagnosis, prognosis and treatment of PCa.