The many faces of long noncoding RNAs.
The many faces of long noncoding RNAs.
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DOI：
10.1111/febs.13101
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发表时间：
2015-05
期刊：
影响因子：
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通讯作者：
Shiekhattar R
中科院分区：
文献类型：
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作者：
Gardini A;Shiekhattar R
在过去的几年里，非编码rna领域已经从遗传学家的小众领域发展成为主流生物学的一个突出领域。基因组技术的进步为哺乳动物基因组提供了更全面的视角，提高了我们对基因组中缺乏蛋白质编码潜力区域的认识。大量证据支持非编码rna在任何给定细胞和组织类型的转录输出中占很大比例的提议。本文将对长链非编码rna的生物学发生和功能作一综述。我们将讨论我们目前对这些分子作为主要染色质参与者的理解，并探索该领域的未来方向。
Over the past few years, the field of noncoding RNAs has grown from a niche for geneticists into a prominent domain of mainstream biology. Advances in genomic technologies have provided a more comprehensive view of the mammalian genome, improving our knowledge of regions of the genome devoid of protein‐coding potential. A large body of evidence supports the proposal that noncoding RNAs account for a large proportion of the transcriptional output of any given cell and tissue type. This review will delve into the biogenesis and function of long noncoding RNAs. We will discuss our current understanding of these molecules as major chromatin players, and explore future directions in the field.