Advances in the study of the mechanochemical coupling of kinesin
Advances in the study of the mechanochemical coupling of kinesin
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DOI：
10.1142/s0217979218400015
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发表时间：
2017-11
影响因子：
1.7
通讯作者：
Ming Li;Z. Ou-Yang;Yao-Gen Shu
中科院分区：
文献类型：
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作者：
Ming Li;Z. Ou-Yang;Yao-Gen Shu
驱动蛋白是一种用于细胞内运输的双头线性马达。它可以在分离之前以双手交替的方式沿着轨道沿着走很长的距离（即，高持续合成能力），并且它每一步消耗一个ATP分子（即，紧密机械化学耦合）。其两个头部的配位机制和机械力化学耦合是众多研究的中心问题。近几十年来，由于单分子技术和分子动力学模拟的发展，已经取得了一些进展。本文综述了驱动蛋白的运动学、能量学、配位机制、机械力化学机制等方面的研究进展。最后对驱动蛋白的未来研究提出了自己的看法。
Kinesin is a two-headed linear motor for intracellular transport. It can walk a long distance in a hand-over-hand manner along the track before detaching (i.e., high processivity), and it consumes one ATP molecule for each step (i.e., tight mechanochemical coupling). The mechanisms of the coordination of its two heads and the mechanochemical coupling are the central issues of numerous researches. A few advances have been made in recent decades, thanks to the development of single-molecule technologies and molecular dynamics simulations. In this paper, we review some progress of the studies on the kinematics, energetics, coordination mechanism, mechanochemical mechanism of kinesin. We also present a personal perspective on the future studies of kinesin.