Autism in Angelman syndrome - An exploration of comorbidity
Autism in Angelman syndrome - An exploration of comorbidity
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DOI：
10.1177/1362361304042720
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发表时间：
2004-06-01
期刊：
影响因子：
5.2
通讯作者：
Ostergaard, JR
中科院分区：
文献类型：
--
作者：
Trillingsgaard, A;Ostergaard, JR
目的是探讨Angelman综合征和自闭症谱系障碍（ASD）之间的共病。Angelman综合征儿童自闭症的识别是一个诊断挑战。在本研究中，16名Angelman综合征儿童，所有15 q11 -13缺失，进行了ASD检查。13名Angelman综合征儿童接受了ASD的ADOS-G算法分类;其余3名在自闭症谱系之外。10人符合自闭症标准，3人符合PDD-NOS标准。将10名患有Angelman综合征和共病自闭症的儿童与8名仅患有自闭症的儿童进行了社交和沟通技能的比较。结果表明，Angelman综合征更好地理解为发育迟缓，而自闭症则是发育异常。结论：Angelman综合征患儿的心理年龄极低，可能是自闭症被过度诊断的原因。
The aim was to explore the comorbidity between Angelman syndrome and autism spectrum disorders (ASDs). Identification of autism in children with Angelman syndrome presents a diagnostic challenge. In the present study, 16 children with Angelman syndrome, all with a 15q11-13 deletion, were examined for ASDs. Thirteen children with Angelman syndrome received an ADOS-G algorithm classification of ASD; the remaining three were outside the autistic spectrum. Ten fulfilled the criteria for autism, and three for PDD-NOS. The 10 children with Angelman syndrome and comorbid autism were compared with eight children with only autism regarding their social and communicative skills. The results indicated that Angelman syndrome is better understood in terms of developmental delay, and autism in terms of developmental deviance. It is concluded that autism might have been overdiagnosed due to the extremely low mental age of the children with Angelman syndrome.