Targeting lipophilic cations to mitochondria
Targeting lipophilic cations to mitochondria
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DOI：
10.1016/j.bbabio.2008.03.029
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发表时间：
2008-07-01
影响因子：
4.3
通讯作者：
Murphy, Michael P.
中科院分区：
文献类型：
--
作者：
Murphy, Michael P.
线粒体功能和功能障碍有助于生物医学研究的一系列重要方面。因此，人们对开发修饰和报告细胞和体内线粒体的方法非常感兴趣。一种方法是将生物活性分子与亲脂性阳离子缀合，将其靶向线粒体。由于线粒体膜电位较大，阳离子在细胞内的线粒体内积累。这种方法已被用来开发针对线粒体的抗氧化剂，选择性地阻止线粒体氧化损伤并防止某些类型的细胞死亡，并用于开发线粒体功能的探针。在这里，我们概述了这些化合物开发的一些背景。 (C) 2008 Elsevier B.V. 保留所有权利。
Mitochondrial function and dysfunction contributes to a range of important aspects of biomedical research. Consequently there is considerable interest in developing approaches to modify and report on mitochondria in cells and in vivo. One approach has been to target bioactive molecules to mitochondria by conjugating them to lipophilic cations. Due to the large mitochondrial membrane potential, the cations are accumulated within mitochondria inside cells. This approach had been used to develop mitochondria-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death and also to develop probes of mitochondrial function. Here we outline some of the background to the development of these compounds. (C) 2008 Elsevier B.V. All rights reserved.