New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis.
New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis.
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DOI：
10.1248/cpb.53.1175
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发表时间：
2005-09
影响因子：
1.7
通讯作者：
M. Ono;Hiroaki Morinaga;C. Masuoka;T. Ikeda;M. Okawa;J. Kinjo;T. Nohara
中科院分区：
文献类型：
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作者：
M. Ono;Hiroaki Morinaga;C. Masuoka;T. Ikeda;M. Okawa;J. Kinjo;T. Nohara
从Lippia dulcis TREV的地上部分分离到两个新的双abolane型倍半萜，lipppiduline A(3)和epilippiduline A(4)。除了五种已知的黄酮类化合物，茜草素(5)，丹参素(6)，桃红素(7)，5-羟基-6,7,3',4'-四甲基甲黄酮(8)和5,3'-二羟基-6,7,4',5'-四甲基甲黄酮(9)，三种已知的苯乙醇苷，脱咖啡因毛蕊花苷（10），actio苷（11）和异actio苷（12），以及两种已知的环烯醚萜苷，8-epiloganin（13）和酰胺（14）。根据光谱数据确定了它们的化学结构。其中，5、7、9的抗氧化活性与α -生育酚基本相同，10 ~ 12的抗氧化活性比α -生育酚强。
Two new bisabolane-type sesquiterpenes, lippidulcine A (3) and epilippidulcine A (4), have been isolated from the aerial parts of Lippia dulcis TREV. along with five known flavonoids, cirsimaritin (5), salvigenin (6), eupatorin (7), 5-hydroxy-6,7,3',4'-tetramethoxyflavone (8) and 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone (9), three known phenylethanoid glycosides, decaffeoylverbascoside (10), acteoside (11) and isoacteoside (12), and two known iridoid glucosides, 8-epiloganin (13) and lamiide (14). Their chemical structures have been determined on the basis of spectroscopic data. Among them, 5, 7, and 9 exhibited almost the same activity as that of alpha-tocopherol, and 10-12 were identified as stronger antioxidants than alpha-tocopherol using the ferric thiocyanate method.