Histones and heart failure in diabetes.
Histones and heart failure in diabetes.
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DOI：
10.1007/s00018-018-2857-1
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Advani A
中科院分区：
文献类型：
--
作者：
Yerra VG;Advani A
虽然心力衰竭现在被认为是糖尿病的主要长期并发症，但最近我们对糖尿病并发症的病理生物学认识的许多进展都是通过对更传统的微血管或大血管疾病的研究来实现的。例如，在糖尿病并发症的表观遗传学进化领域，尤其是组蛋白的翻译后修饰领域，就是这样的情况。然而，组蛋白修饰也发生在人类心力衰竭中，它们的扰动也发生在糖尿病心脏中。在这里，我们回顾了迄今为止已被研究的主要组蛋白修饰及其酶的作者和擦除器；我们讨论了目前已知的它们在心力衰竭和糖尿病心脏中的作用；我们从微血管和大血管并发症的研究中吸取了经验教训；我们推测，治疗操纵组蛋白修饰可能会改变糖尿病心力衰竭的自然历史。
Although heart failure is now accepted as being a major long-term complication of diabetes, many of the recent advances in our understanding of the pathobiology of diabetes complications have come about through the study of more traditional microvascular or macrovascular diseases. This has been the case, for example, in the evolving field of the epigenetics of diabetes complications and, in particular, the post-translational modification of histone proteins. However, histone modifications also occur in human heart failure and their perturbation also occurs in diabetic hearts. Here, we review the principal histone modifications and their enzymatic writers and erasers that have been studied to date; we discuss what is currently known about their roles in heart failure and in the diabetic heart; we draw on lessons learned from the studies of microvascular and macrovascular complications; and we speculate that therapeutically manipulating histone modifications may alter the natural history of heart failure in diabetes.
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