Brief Report: Comparison of Continuous Glucose Monitoring and Finger-Prick Blood Glucose Levels in Hospitalized Patients Administered Basal-Bolus Insulin
Brief Report: Comparison of Continuous Glucose Monitoring and Finger-Prick Blood Glucose Levels in Hospitalized Patients Administered Basal-Bolus Insulin
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DOI：
10.1089/dia.2012.0282
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发表时间：
2013-03-01
影响因子：
5.4
通讯作者：
Stranks, Stephen N.
中科院分区：
文献类型：
--
作者：
Burt, Morton G.;Roberts, Gregory W.;Stranks, Stephen N.
背景资料：以前的研究通过每天测量四次手指采血血糖水平（BGL）来评估基础-餐时胰岛素（BBI）在住院患者中的疗效。本研究的目的是调查这种BGL监测方案是否能准确反映接受BBI治疗的住院患者的血糖水平。我们假设，四个读数中的三个是餐前，手指刺破BGL会低估平均glucose concentration.Subjects和方法：26个连续的同意与1型（n = 3）或2型（n = 23）糖尿病患者入院，并给予甘精胰岛素每日一次和速效胰岛素餐前进行连续血糖监测长达72小时。在每次主餐前（0700、1200和1700 h）和2100 h进行手指点刺BGL。结果：通过动态血糖监测和手指点刺BGL评估时，平均每日葡萄糖浓度无显著差异（9.6 +/- 2.4 vs. 9.6 +/- 2.7 mmol/L，P = 0.84）。Bland-Altman图显示了两种葡萄糖浓度测量方法之间的一些变异性，但无偏倚。连续血糖监测记录了88例餐后高血糖波动; 61例（69%）通过手指针刺BGL监测确定。有10次葡萄糖波动
Background: Previous studies have assessed the efficacy of basal-bolus insulin (BBI) in hospitalized patients by measuring four finger-prick blood glucose levels (BGLs) per day. The aim of this study was to investigate whether this BGL monitoring regimen provides an accurate reflection of glycemia in hospitalized patients administered BBI. We hypothesized that, as three of four readings are preprandial, finger-prick BGLs would underestimate the mean glucose concentration.Subjects and Methods: Twenty-six consecutive consenting subjects with type 1 (n = 3) or type 2 (n = 23) diabetes mellitus admitted to the hospital and administered insulin glargine once daily and rapid-acting insulin before meals underwent continuous glucose monitoring for up to 72 h. Finger-prick BGLs were performed before each main meal (0700, 1200, and 1700 h) and at 2100 h.Results: Mean daily glucose concentration was not significantly different when assessed by continuous glucose monitoring and finger-prick BGLs (9.6 +/- 2.4 vs. 9.6 +/- 2.7 mmol/L, P = 0.84). A Bland-Altman plot revealed some variability but no bias between the two methods of measurement of glucose concentration. There were 88 postprandial hyperglycemic excursions recorded on continuous glucose monitoring; 61 (69%) were identified by finger-prick BGL monitoring. There were 10 glucose excursions