case-control studyの手法を用いた胃癌死亡減少に対する胃癌集団検診の効果の疫学的評価
case-control studyの手法を用いた胃癌死亡減少に対する胃癌集団検診の効果の疫学的評価
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病例对照研究方法流行病学评价胃癌大规模筛查对降低胃癌死亡率的影响
DOI：
10.11405/nisshoshi1964.92.836
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
好和 南原
中科院分区：
文献类型：
--
作者：
陽介 阿部;徹 光島;京平 永谷;仁 井熊;好和 南原
采用病例对照研究方法，对胃癌筛查对胃癌死亡的保护作用进行了流行病学评价。同时，为了更有效地开展筛查工作，分析了应重点推荐筛查的年龄组和最佳筛查间隔时间。从千叶癌症登记处中确定了1981-1989年千叶县阿波地区死于胃癌的男性527例和女性273例。每例病例随机抽取3个对照组，对照组按居住地区、性别和出生年份3年内严格匹配，阿波市常住居民（1989年全国人口普查约16.2万人）。对于病例和对照，通过与筛查证明进行比较，分别收集每个匹配集中病例至诊断日期的筛查史信息。结果显示，与从未接受过筛查的男性相比，接受过筛查的男性的相对风险为0.417（99%CI 0.284-0.612），女性为0.480（99%CI 0.280-0.823）。在40-74岁男性和50-69岁女性年龄组中，集中观察到风险显著降低，并且自上次筛查以来的三年内，保护作用最多持续。为了提高筛查计划的效率，应强烈建议这些年龄组接受筛查，并且允许自上次阴性检测以来的最佳筛查时间间隔最多为3年。
: An epidemiological evaluation of the protective effect for dying of stomach cancer by screening programme for stomach cancer was conducted with applying a method of case-control study. And also in order to carry out an efficient screening programme, the age groups who should be intensively recommended to receive screening and an optimal screening time interval since the last test were analyzed. 527 cases of men and 273 of women, dying of stomach cancer in the years 1981-1989 in the Awa region of Chiba prefecture, were identified from Chiba Cancer Registry. For each case, 3 controls were drawn at random from Awa living residents (about 162000 inhabitants at 1989 national census), with being matched strictly according to the district of residence, sex and born within 3 years of birth-year. For both cases and controls, the information about the screening history until the date of diagnosis of the case in each matched set was collected respectively from comparison with the screening certification. The results showed a relative risk of 0.417 (99% CI 0.284-0.612) in ever screened men compared with never screened and 0.480 (99% CI 0.280-0.823) in women. The significant reduction in risk was intensively observed on age groups 40-74 years among men and 50-69 years among women and the protective effect continued at most in the following three years since last screening. For an efficiency of screening programme, these age groups should be intensively recommended to receive screening and it is allowable that an optimal screening time interval since last negative test is at most 3 years for general attendance.