Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment.
Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment.
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一般认知能力与教育程度遗传位点之间关联的独立证据。
DOI：
10.1002/ajmg.b.32319
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Lundervold
中科院分区：
文献类型：
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作者：
Trampush,JoeyW;Lencz,Todd;Knowles,Emma;Davies,Gail;Guha,Saurav;Pe'er,Itsik;Liewald,DavidC;Starr,JohnM;Djurovic,Srdjan;Melle,Ingrid;Sundet,Kjetil;Christoforou,Andrea;Reinvang,Ivar;Mukherjee,Semanti;DeRosse,Pamela;Lundervold
认知缺陷和教育成绩下降在精神疾病中很常见；了解认知和教育缺陷的遗传基础可能有助于了解精神障碍的病因学。最近的一项大型全基因组关联研究(Gwas)报告了一个经过多年教育的全基因组显著基因座，随后证明在重叠的队列中与一般认知能力(G)有关。目前的研究旨在测试在一个独立的、大规模的队列集合中，受教育程度的GWAS命中是否与一般认知能力有关。利用认知基因组学联盟中的队列(有说服力的；多达20,495名健康人)，我们检查了与教育程度相关的基因和变异之间的关系。接下来，我们用来自教育程度研究的神经认知数据对24,189名个体进行了荟萃分析，然后对53,188名基本上独立的个体进行了荟萃分析，这些个体来自最近的认知GWA。位于染色体6q16.1上的一个SNP(Rs1906252)与遗传易感性显著相关(P= 1.47 × 10−4)。对43,381个非重叠个体进行的第一次联合分析具有极显著意义(P= 4.94 × 10−7)，对68,159个非重叠个体的第二次联合分析更为稳健(P= 1.65 × 10−9)。这些结果在大规模数据集中提供了与认知功能和教育相关的遗传位点的独立复制。随着样本量的增加，认知型GWA将识别越来越多的相关基因座，就像在其他多基因数量性状中所完成的那样，这可能与精神疾病有关。©2015 Wiley期刊，Inc.
Cognitive deficits and reduced educational achievement are common in psychiatric illness; understanding the genetic basis of cognitive and educational deficits may be informative about the etiology of psychiatric disorders. A recent, large genome‐wide association study (GWAS) reported a genome‐wide significant locus for years of education, which subsequently demonstrated association to general cognitive ability (“g”) in overlapping cohorts. The current study was designed to test whether GWAS hits for educational attainment are involved in general cognitive ability in an independent, large‐scale collection of cohorts. Using cohorts in the Cognitive Genomics Consortium (COGENT; up to 20,495 healthy individuals), we examined the relationship betweengand variants associated with educational attainment. We next conducted meta‐analyses with 24,189 individuals with neurocognitive data from the educational attainment studies, and then with 53,188 largely independent individuals from a recent GWAS of cognition. A SNP (rs1906252) located at chromosome 6q16.1, previously associated with years of schooling, was significantly associated withg(P= 1.47 × 10−4) in COGENT. The first joint analysis of 43,381 non‐overlapping individuals for thisa priori‐designated locus was strongly significant (P= 4.94 × 10−7), and the second joint analysis of 68,159 non‐overlapping individuals was even more robust (P= 1.65 × 10−9). These results provide independent replication, in a large‐scale dataset, of a genetic locus associated with cognitive function and education. As sample sizes grow, cognitive GWAS will identify increasing numbers of associated loci, as has been accomplished in other polygenic quantitative traits, which may be relevant to psychiatric illness. © 2015 Wiley Periodicals, Inc.