Tissue plasminogen activator (t-PA) and placental plasminogen activator inhibitor (PAI-2) in gingival fluid from 8-9-year-old children.
Tissue plasminogen activator (t-PA) and placental plasminogen activator inhibitor (PAI-2) in gingival fluid from 8-9-year-old children.
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8-9 岁儿童牙龈液中的组织纤溶酶原激活剂 (t-PA) 和胎盘纤溶酶原激活剂抑制剂 (PAI-2)。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
B. Sundin
中科院分区：
文献类型：
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作者：
B. Kinnby;M. Borgström;L. Granath;I. Lecander;B. Sundin
高浓度的组织型纤溶酶原激活剂（t-PA）和胎盘型纤溶酶原激活剂抑制剂（PAI-2）已被发现在成人龈沟液（GCF）。在本研究中，对16名8-9岁儿童的GCF水平进行了检测。GCF的采样是用Millipore-filter的小圆盘进行的。采用酶联免疫吸附法分析t-PA和PAI-2，方法误差低。t-PA平均浓度略高于成人，pai -2平均浓度略低于成人。一项比较儿童健康部位和炎症部位的个体研究显示，炎症部位的GCF浓度略高。t-PA和PAI-2之间的平衡未见变化。
High concentrations of tissue plasminogen activator (t-PA) and placental type plasminogen activator inhibitor (PAI-2) have previously been found in gingival crevicular fluid (GCF) of adults. In the present study, the levels were examined in 16 children aged 8-9 yr. Sampling of GCF was performed with small disks of Millipore-filter. t-PA and PAI-2 were analyzed with enzyme-linked immunosorbent assays with low method errors. The mean concentration of t-PA was slightly higher than in adults, while the mean PAI-2-concentration was slightly lower. An intraindividual study comparing healthy and inflamed sites in the children showed slightly higher concentrations in GCF from inflamed sites. No change was observed in the balance between t-PA and PAI-2.