Salivary gland carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology
Salivary gland carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology
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DOI：
10.1186/s12885-019-5564-x
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发表时间：
2019-04-11
期刊：
影响因子：
3.8
通讯作者：
Zhang, Zhi-Yuan
中科院分区：
文献类型：
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作者：
Fu, Jin-Ye;Wu, Chun-Xiao;Zhang, Zhi-Yuan
研究背景：涎腺癌在头颈部恶性肿瘤中居第六位，发病率相对较低。流行病学研究大多基于机构数据，导致在发病率评估中存在选择偏差。由于国际疾病编码，大多数基于人群的癌症登记将小唾液腺癌症与口腔癌分组，而不是将整个唾液腺癌分组。因此，涎腺癌的发病率还没有得到很好的评估。本研究的目的是评估2003-2012年上海市小、大涎腺恶性肿瘤的发病情况，并对其发病部位和组织分布进行分析。方法：收集上海市肿瘤登记系统2003-2012年诊断为大、小涎腺恶性肿瘤的病例资料。相关的社会人口学数据来自上海市公安局。年龄标化发病率直接按世界标准人口计算。通过比较第一个五年和下一个五年的发病率来分析研究期间发病率的变化。结果：共发现肿瘤1831例，占同期恶性肿瘤总数的0.35%。男性和女性的平均年龄分别为59岁和57岁。年龄标化发病率为7.99/100万人年，男女比例为1.10。在这10年期间，发病率没有显著变化。腮腺、颌下腺和小腺的解剖分布符合4：1：2的规律。在男性中，腺癌是最常见的组织类型，其次是粘液表皮样癌；在女性中，粘液表皮样癌是最常见的组织类型，其次是腺样囊性癌。然而，年龄和性别在部位和组织学类型上的分布差异表明病因学上的差异，值得进一步研究。
Background: Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor salivary glands with oral cancer instead of with salivary gland carcinoma as a whole, because of the international disease coding. Thus, the incidence of salivary gland carcinoma has not been well assessed. The aim of the study is to evaluate the incidence of both minor and major salivary gland cancers in Shanghai during the years 2003-2012, and to analyse the site and histological distributions.Methods: Data from the Shanghai Cancer Registry system were extracted for patients diagnosed with malignancies of the major or minor salivary glands for the year 2003 to 2012. Pertinent socio-demographic data were obtained from the Shanghai Municipal Bureau of Public Security. The age-standardized incidence rates were calculated directly according to the world standard population. The change in incidence during the study period was analysed by comparing the rates during the first and next five years. The distributions of anatomic subsites and histology were also analysed.Results: A total of 1831 cases were identified, representing 0.35% of all malignancies during the study period. The median age was 59 and 57 years for men and women, respectively. The age-standardized incidence was 7.99 per 1,000,000 person-year, with a male-to-female ratio of 1.10. There was no significant change in the incidence during the 10-year period. The anatomic distribution confirmed the 4:1:2 rule for the parotid, submandibular, and minor glands. In men, adenocarcinoma not otherwise specified was the most common histological type followed by mucoepidermoid; in women, the mucoepidermoid was the most common histotype, followed by the adenoid cystic.Conclusion: Salivary gland carcinoma is relatively rare in incidence. However, the variations in age and sex distribution in sites and histology types suggest differences in aetiology which warrants further investigation.