Preparation of reactive oxygen species-responsive antibacterial hydrogels for efficient anti-infection therapy
Preparation of reactive oxygen species-responsive antibacterial hydrogels for efficient anti-infection therapy
复制标题
活性氧响应抗菌水凝胶的制备用于高效抗感染治疗
DOI：
10.1016/j.matlet.2019.127254
复制
发表时间：
2020-03-15
影响因子：
3
通讯作者：
Ma, Ting
中科院分区：
文献类型：
--
作者：
Hu, Jingxuan;Liu, Zijing;Ma, Ting
In this study, we prepared a novel reactive oxygen species (ROS)-responsive antibacterial hydrogel (named PAAg-PGFe), which is composed of silver nanoparticle (AgNP)-contained polyacrylic acid (PA) and Fe2+/Fe3+-contained polyglutamic acid (PG). The hydrogel remained stable under the normal condition but rapidly broke down when encountering ROS. The hydrogel exhibited strong capacity of inhibiting pathogenic Pseudomonas aeruginosa cells but had no obvious toxicity to mammalian cells. In vivo experiments further showed that the hydrogel have excellent anti-infection ability, leading to quick wound healing and pathogen removal. This study provides a novel strategy of preparing stimuli-responsive hydrogels, facilitating the application of hydrogels in anti-infection therapy. (C) 2019 Elsevier B.V. All rights reserved.
