Inhibition of TNF-α sepsis of lipopolysaccharide induction using nano cerium oxide system
Inhibition of TNF-α sepsis of lipopolysaccharide induction using nano cerium oxide system
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DOI：
10.1016/j.msec.2017.03.207
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发表时间：
2017-08-01
影响因子：
7.9
通讯作者：
Zhu, Guoji
中科院分区：
文献类型：
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作者：
Ge, Lingqing;Hu, Qiaozhen;Zhu, Guoji
脓毒症是当今世界地球仪面临的主要威胁之一，是导致高死亡率的主要原因。为了治疗脓毒症，只有很少的报告已经提出了与抗氧化剂的帮助。本文阐述了葡萄中富含抗氧化剂，利用葡萄中富含抗氧化剂的提取物合成了环境友好的氧化铈纳米颗粒（CeO 2 NPs）。此外，对合成的CeO 2 NP进行各种表征研究，得到37 nm的尺寸，具有团聚的球形颗粒。进一步合成的CeO 2纳米颗粒通过大鼠的尾神经在体内进行治疗脓毒症。CeO 2 NPs阻止TNF-α的释放，并倾向于增加肝脏中的二氧化铈水平。进行了组织学研究并进行了报告。所得结果经方差分析LSD-Tukey检验具有统计学显著性，并在本文中进行了研究和报告。(C)2017爱思唯尔B. V.保留所有权利。
Nowadays sepsis was one of the major threatening.issues all over the globe which majorly causes death in high rate. To treat sepsis only few reports have been proposed with the help of anti-oxidants. This manuscript stated that the grape is rich in anti-oxidant, with the help of anti-oxidant rich grape extract Cerium oxide nanoparticles (CeO2 NPs) were synthesized eco-friendly. Further the synthesized CeO2 NPs subjected for various characterization studies which resulted in 37 nm of size with agglomerated spherical shape particles. Further synthesized CeO2 NPs were subjected in vivo through tail nerves of rats to treat sepsis. CeO2 NPs stops the release TNF-alpha and tends to increase the ceria level in liver. Histopathological studies were performed and also reported. The obtained results were statistically significant with ANOVA LSD-Tukey's test were studied and reported in this manuscript. (C) 2017 Elsevier B.V. All rights reserved.