Preparation, purification, and analysis of alkylated cyclodextrins
Preparation, purification, and analysis of alkylated cyclodextrins
复制标题
烷基化环糊精的制备、纯化和分析
DOI：
10.1002/jhrc.1240150904
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
H. Husmann
中科院分区：
文献类型：
--
作者：
G. Schomburg;A. Deege;H. Hinrichs;E. Hübinger;H. Husmann
从反应参数、烷基化程度和产率等方面对α-、β-和γ-环糊精的烷基化方法进行了优化。通过高温GC和HPLC对反应混合物和分离的单一物质进行了分析。通过改变固定相和移动的相，对优选应用的HPLC的相系统进行了仔细的调节，以适应已合成的各种烷基化CD物质的非常不同的疏水性。从制备规模HPLC分离中以高纯度分离出几种部分或完全烷基化的CD物质。
Methods of alkylation of α-, β- and γ-cyclodextrins have been optimized with regard to the parameters of reaction, degree of alkylation and yields. The analysis of the reaction mixtures and of the isolated single species has been performed by high temperature GC and HPLC. The phase systems of the preferably applied HPLC have been carefully adjusted by variation of both the stationary and mobile phases to the very different hydrophobicities of the various alkylated CD species which have been synthesized. Several partially or fully alkylated CD species were isolated from preparative scale HPLC separations in high purity.