ACTIVITY AND MODULATION OF ORNITHINE DECARBOXYLASE AND CONCENTRATIONS OF POLYAMINES IN VARIOUS TISSUES OF RATS AS A FUNCTION OF AGE
ACTIVITY AND MODULATION OF ORNITHINE DECARBOXYLASE AND CONCENTRATIONS OF POLYAMINES IN VARIOUS TISSUES OF RATS AS A FUNCTION OF AGE
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DOI：
10.1016/0531-5565(82)90042-0
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发表时间：
1982-01-01
影响因子：
3.9
通讯作者：
KANUNGO, MS
中科院分区：
文献类型：
--
作者：
DAS, R;KANUNGO, MS
本文研究了4（幼年）、38（成年）和85周龄雄性大鼠大脑皮质、心和肺的可溶性和核性鸟氨酸脱羧酶（ODC）活性。此外，氨茶碱，组胺和雌二醇对可溶性ODC的活性的影响进行了测定，在这些组织的切片在体外。ODC活性在所有组织的可溶性部分中显著高于核部分。它的活性在这两个馏分中是最高的未成熟的，并随着年龄的增加而减少，在所有的组织中，除了在肺的核部分，它随着年龄的增长而增加。心、肺和大脑皮层的ODC似乎不同，这从它们对氨茶碱、组胺和雌二醇的敏感性的差异中可以看出。一般来说，随着年龄的增长，其对3种效应物的敏感性降低。这可能是由于受体的减少和ODC活性的伴随降低。不同年龄大鼠脑内ODC活性与多胺水平有直接关系。
Activities of ornithine decarboxylase (ODC) on the soluble and nuclear fractions of the cerebral cortex, heart and lungs of 4 (young), 38 (adult) and 85 wk old male rats were studied. Also, the effects of aminophylline, histamine and estradiol on the activity of soluble ODC were determined in vitro in slices of these tissues. ODC activity is significantly higher in the soluble fraction of all the tissues in comparison to that of nuclear fraction. Its activity in both the fractions is highest in the immature and decreases with increasing age in all the tissues except in the nuclear fraction of the lungs in which it increases with age. The ODC of the heart, lungs and cerebral cortex appear to be different as seen from the differences in their sensitivities to aminophylline, histamine and estradiol. In general, there is a decrease in its sensitivity to the 3 effectors with increasing age. This may be due to a decrease in the receptors and a concomitant decrease in ODC activity. A direct relationship between ODC activity and polyamine levels of the brain exists at various ages of the rat.