The short-term effects of soft pellets on lipogenesis and insulin sensitivity in rats.
The short-term effects of soft pellets on lipogenesis and insulin sensitivity in rats.
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软颗粒对大鼠脂肪生成和胰岛素敏感性的短期影响。
DOI：
10.3746/pnf.2014.19.3.164
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发表时间：
2014-09
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Date Y
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作者：
Bae CR;Hasegawa K;Akieda-Asai S;Kawasaki Y;Cha YS;Date Y
本研究的目的是调查12天，软颗粒（SP）饮食与3小时限制喂养时间表的热量摄入，体重，脂质代谢和胰岛素敏感性的短期影响。葡萄糖和胰岛素水平测量前，中期，和后喂养。与喂食对照颗粒（CP）的大鼠相比，SP大鼠表现出餐后高血糖。SP大鼠餐时胰岛素反应性显著高于CP大鼠。SP和CP大鼠肝脏三酰甘油含量和脂肪生成基因mRNA水平无显著差异。而SP大鼠肝细胞轻度肥大。此外，组织学分析显示，SP大鼠的胰腺具有比CP大鼠更多的胰岛面积。这项研究表明，喂食仅含SP的饮食12天会导致葡萄糖耐受不良，这表明食用可吸收的食物（如软质饮食）可能会引发葡萄糖代谢不足并导致危及生命的疾病。
The purpose of the present study was to investigate the short-term effects of a 12-day, soft pellet (SP) diet with a 3-h restricted feeding schedule on caloric intake, body weight, lipid metabolism, and insulin sensitivity. Glucose and insulin levels were measured pre-, mid-, and post-feeding. The SP rats exhibited postprandial hyperglycemia compared to rats fed control pellets (CP). The insulin response of SP rats during a meal was significantly higher than that of CP rats. There were no significant differences in the hepatic triacylglycerol contents and lipogenesis gene mRNA levels of SP and CP rats. However, the hepatocytes of SP rats were slightly hypertrophic. In addition, histological analysis revealed that the pancreases of SP rats had more islet areas than those of CP rats. This study demonstrated that feeding an SP-only diet for 12 days induces glucose intolerance, suggesting that the consumption of absorbable food, like a soft diet, may trigger glucose metabolism insufficiency and lead to life-threatening diseases.