Effects of neurotensin on the isolated mouse distal colon.
Effects of neurotensin on the isolated mouse distal colon.
复制标题
神经降压素对离体小鼠远端结肠的影响。
DOI：
10.1016/0014-2999(85)90052-4
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发表时间：
1985
影响因子：
5
通讯作者：
P. Lebrun
中科院分区：
文献类型：
--
作者：
J. Fontaine;P. Lebrun
J. FONTAINE 和 P. LEBRUN，神经降压素对离体小鼠远端结肠的影响，欧洲 J. Pharmacol。 107 (1985) 141–147. 在离体小鼠远端结肠中研究了神经降压素的作用。该肽具有有效的刺激作用，根据所使用的浓度，其产生于连接前或连接后。在低浓度（10−11−10−10M）下，神经降压素诱导神经源性非胆碱能收缩，这似乎是由肠兴奋性神经释放 P 物质（或 P 物质样活性）引起的。在较高浓度（10−9−10−7M）下，神经降压素引起双相效应，包括快速短暂松弛和肌源性收缩。蜂毒毒素 apanim 抑制 NT 诱导的舒张，而吲哚美辛抑制前列腺素合成则消除了收缩期。所有这些反应都与细胞外Ca2+浓度密切相关。神经降压素的这些特性表明该肽可能发挥结肠运动调节剂的作用。
J. FONTAINE and P. LEBRUN,Effects of neurotensin on the isolated mouse distal colon, European J. Pharmacol. 107 (1985) 141–147.The effects of neurotensin were studied in the isolated mouse distal colon. This peptide had potent stimulatory effects which were of pre- or postjunctional origin according to the concentrations used. At low concentrations (10−11−10−10M) neurotensin induced neurogenic non-cholinergic contractions which seemed to result from the release of substance P (or substance P-like activity) by enteric excitatory nerves. At higher concentrations (10−9−10−7M) neurotensin elicited a biphasic effect consisting of transient relaxation rapidly followed by myogenic contraction. The bee venom toxin apanim inhibited the NT-induced relaxation while inhibition of prostaglandin synthesis by indomethacin abolished the contraction phase. All these responses were tightly related to the extracellular Ca2+concentration. These properties of neurotensin point to a possible role for this peptide as a modulator of colonic motility.
前列腺素合成抑制剂对神经降压素和水杨酸钠诱导的大鼠胃细胞保护的影响。
影响因子：
6.1
作者：
Adcock,JE;Hernandez,DE;Nemeroff,CB;PrangeJr,AJ
通讯作者：
PrangeJr,AJ