The Metabolic Phenotype of Prostate Cancer.
The Metabolic Phenotype of Prostate Cancer.
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DOI：
10.3389/fonc.2017.00131
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发表时间：
2017
影响因子：
4.7
通讯作者：
Siddiqui MM
中科院分区：
文献类型：
--
作者：
Eidelman E;Twum-Ampofo J;Ansari J;Siddiqui MM
前列腺癌是美国男性中最常见的非皮肤癌症。肿瘤代谢已成为一个当代话题，对提高对肿瘤发生机制的理解有很大的兴趣。从代谢的角度来看，前列腺癌是一种非常有趣的疾病模型。前列腺组织在基线条件下表现出独特的代谢活动。良性前列腺细胞会积累锌，而这些多余的锌会抑制柠檬酸的氧化和柠檬酸循环中的代谢，从而有效地产生柠檬酸。然而，恶性细胞会主动氧化柠檬酸，恢复更典型的柠檬酸循环功能。更令人感兴趣的是，前列腺癌没有表现出沃伯格效应，即在许多其他癌症中看到的葡萄糖摄取增加。这些细胞代谢差异和其他差异具有临床意义，因为它们提供了各种潜在的治疗靶点。此外，了解良性前列腺癌与低级别和高级别前列腺癌之间的代谢谱差异也为更好地了解癌症进展和开发新的诊断测试提供了途径。本文就前列腺癌代谢表型的研究现状进行综述。
Prostate cancer is the most common non-cutaneous cancer in men in the United States. Cancer metabolism has emerged as a contemporary topic of great interest for improved mechanistic understanding of tumorigenesis. Prostate cancer is a disease model of great interest from a metabolic perspective. Prostatic tissue exhibits unique metabolic activity under baseline conditions. Benign prostate cells accumulate zinc, and this excess zinc inhibits citrate oxidation and metabolism within the citric acid cycle, effectively resulting in citrate production. Malignant cells, however, actively oxidize citrate and resume more typical citric acid cycle function. Of further interest, prostate cancer does not exhibit the Warburg effect, an increase in glucose uptake, seen in many other cancers. These cellular metabolic differences and others are of clinical interest as they present a variety of potential therapeutic targets. Furthermore, understanding of the metabolic profile differences between benign prostate versus low- and high-grade prostate cancers also represents an avenue to better understand cancer progression and potentially develop new diagnostic testing. In this paper, we review the current state of knowledge on the metabolic phenotypes of prostate cancer.