Relationship between circulating plasma matrix metalloproteinase-9 (gelatinase-B) concentration and aortic root dilatation
Relationship between circulating plasma matrix metalloproteinase-9 (gelatinase-B) concentration and aortic root dilatation
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DOI：
10.1016/j.amjhyper.2005.08.013
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发表时间：
2006-04-01
影响因子：
3.2
通讯作者：
Kaymaz, C
中科院分区：
文献类型：
--
作者：
Karakaya, O;Barutcu, I;Kaymaz, C
背景资料：基质金属蛋白酶（MMP）在主动脉夹层和动脉瘤中的表达表明与正常主动脉相比蛋白水解增加。然而，其在主动脉根部扩张发展中的作用尚未研究。因此，我们试图确定主动脉根部直径和MMP-9浓度之间的关系，在高血压population.Methods：53例高血压患者（n = 27）和无主动脉扩张（n = 26）被列入研究。所有参与者都接受了完整的经胸超声心动图检查，包括主动脉根部测量。采用一步法夹心酶联免疫法测定两组患者血浆MMP-9浓度并进行比较。超声心动图评价无明显瓣膜病变和室壁运动异常。超声心动图检查，只有5例患者有二叶主动脉瓣。在主动脉根部扩张的患者中，21例患者正在使用抗高血压药物，而在没有主动脉根部扩张的患者中，19例患者正在使用抗高血压药物。主动脉根部扩张患者的血浆MMP-9水平显著高于无扩张患者（2.5 +/- 1.0 nu 1.6 +/- 0.9 ng/mL; P = 0.003）。相关性分析发现，主动脉直径与血浆MMM-9水平呈正相关（r = 0.43，P = 0.001）。结论：主动脉根部扩张与较高的MMP释放有关，这可能表明胶原溶解和弹性蛋白溶解活性增加在高血压诱导的主动脉根部扩张中的作用。(c)2006年美国高血压杂志有限公司
Background: Expression of matrix metalloproteinase (MMP) has been shown in aortic dissection and aneurysms indicating increased proteolysis compared with the normal aorta. However, its role in the development of aortic root dilatation has not been studied. We therefore attempted to determine the relationship between aortic root diameter and MMP-9 concentration in a hypertensive population.Methods: The 53 hypertensive patients with (n = 27) and without aortic dilatation (n = 26) were included in the study. All participants underwent a complete transthoracic echocardiographic examination including aortic root measurement. Plasma concentration of MMP-9 were determined by the one-step sandwich enzyme immunoassay method and compared in both groups.Results: Baseline demographic properties were similar in both groups. No subject had significant valvular disorder and wall motion abnormality on echocardiographic evaluation. On echocardiographic examination only five patients had bicuspid aortic valve. In patients with aortic root dilatation, 21 patients were using an antihypertensive agent, whereas in patients without aortic root dilatation, 19 patients were using an antihypertensive agent. Plasma MMP-9 level was significantly higher in patients with aortic root dilatation than in those without dilatation (2.5 +/- 1.0 nu 1.6 +/- 0.9 ng/mL; P =.003). On correlation analysis, we found a positive correlation between aortic diameter and plasma MMM-9 levels (r = 0.43, P = .001).Conclusions: Aortic root dilatation is associated with higher MMP release, which may indicate the role of increased collagenolytic and elastolytic activities in hypertension-induced aortic root dilatation. (c) 2006 American Journal of Hypertension, Ltd.