Local Integration Accounts for Weak Selectivity of Mouse Neocortical Parvalbumin Interneurons.
Local Integration Accounts for Weak Selectivity of Mouse Neocortical Parvalbumin Interneurons.
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DOI：
10.1016/j.neuron.2015.06.030
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发表时间：
2015-07-15
期刊：
影响因子：
16.2
通讯作者：
Zemelman BV
中科院分区：
文献类型：
--
作者：
Scholl B;Pattadkal JJ;Dilly GA;Priebe NJ;Zemelman BV
剖析兴奋性神经元和抑制性神经元在皮质环路中的功能作用是神经科学的一个基本目标。特别令人感兴趣的是它们在紧急皮质计算中的作用，例如初级视觉皮质(V1)的双眼整合。我们测量了基因定义的兴奋性和抑制性神经元亚群的双眼反应选择性。小白蛋白(PV+)中间神经元接受来自双眼的强输入，但缺乏对双眼视差的选择性。由于来自邻近神经元的异质突触输入可能导致广泛的选择性，我们研究了单个PV+中间神经元的选择性与主要由兴奋性神经元组成的局部神经元网络的选择性。PV+神经元在空间距离上表现出与邻近神经元群体的功能相似，类似于突触连接的测量。另一方面，表达CaMKIIα的兴奋性神经元与邻近群体没有这种功能相似性。我们的发现表明，PV+中间神经元的广泛选择性是局部网络内非特异性整合的结果。
Dissecting the functional roles of excitatory and inhibitory neurons in cortical circuits is a fundamental goal in neuroscience. Of particular interest are their roles in emergent cortical computations such as binocular integration in primary visual cortex (V1). We measured the binocular response selectivity of genetically-defined subpopulations of excitatory and inhibitory neurons. Parvalbumin (PV+) interneurons received strong inputs from both eyes, but lacked selectivity for binocular disparity. Because broad selectivity could result from heterogeneous synaptic input from neighboring neurons, we examined how individual PV+ interneuron selectivity compared to that of the local neuronal network, which is primarily composed of excitatory neurons. PV+ neurons showed functional similarity to neighboring neuronal populations over spatial distances resembling measurements of synaptic connectivity. On the other hand, excitatory neurons expressing CaMKIIα displayed no such functional similarity with the neighboring population. Our findings suggest that broad selectivity of PV+ interneurons results from nonspecific integration within local networks.