Cancer Cases from ACRIN Digital Mammographic Imaging Screening Trial: Radiologist Analysis with Use of a Logistic Regression Model
Cancer Cases from ACRIN Digital Mammographic Imaging Screening Trial: Radiologist Analysis with Use of a Logistic Regression Model
复制标题
DOI：
10.1148/radiol.2522081457
复制
发表时间：
2009-08-01
期刊：
影响因子：
19.7
通讯作者：
Gatsonis, Constantine
中科院分区：
文献类型：
--
作者：
Pisano, Etta D.;Acharyya, Suddhasatta;Gatsonis, Constantine
目的：确定哪些因素影响数字乳房摄影影像筛查试验(DMIST)的癌症检测结果。材料和方法：该项目符合HIPAA标准，并获得机构审查委员会的批准。七位放射科医生读者回顾了DMIST癌症病例中的胶片硬拷贝(屏幕胶片)和数字乳房X光照片，并评估了在这两种类型的图像上导致病变可见性的因素。使用两个多项Logistic回归模型分析读者对数字和屏幕胶片图像的合并和压缩可见度。结果：读者最常将DMIST癌症可见度的差异归因于数字和屏幕胶片钼靶摄影图像对比度的差异，而不是位置或压缩的差异。即使对患者年龄、病变类型和乳房X光摄影系统进行了调整，乳房致密的女性患乳腺癌的几率也明显高于乳房不致密的女性(优势比，2.28；P
Purpose: To determine which factors contributed to the Digital Mammographic Imaging Screening Trial (DMIST) cancer detection results.Materials and Methods: This project was HIPAA compliant and institutional review board approved. Seven radiologist readers reviewed the film hard-copy (screen-film) and digital mammograms in DMIST cancer cases and assessed the factors that contributed to lesion visibility on both types of images. Two multinomial logistic regression models were used to analyze the combined and condensed visibility ratings assigned by the readers to the paired digital and screen-film images.Results: Readers most frequently attributed differences in DMIST cancer visibility to variations in image contrast-not differences in positioning or compression-between digital and screen-film mammography. The odds of a cancer being more visible on a digital mammogram-rather than being equally visible on digital and screen-film mammograms were significantly greater for women with dense breasts than for women with nondense breasts, even with the data adjusted for patient age, lesion type, and mammography system (odds ratio, 2.28; P